E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)
1_MWATC 6_ CNWFC 11_ LDGQP 16_ EEVPP 21_ PQGAR 26_ MQAYS 31_ NPGYS 36_ SFPSP 41_ TGLEP 46_ SCKSC 51_ GAHFA 56_ NTARK 61_ QTCLD 66_ CKKNF 71_ CMTCS 76_ SQVGN 81_ GPRLC 86_ LLCQR 91_ FRATA 96_ FQREE 101_ LMKMK 106_ VKDLR 111_ DYLSL 116_ HDIST 121_ EMCRE 126_ KEELV 131_ LLVLG 136_ QQPVI 141_ SQEDR 146_ TRAST 151_ LSPDF 156_ PEQQA 161_ FLTQP 166_ HSSMV 171_ PPTSP 176_ NLPSS 181_ SAQAT 186_ SVPPA 191_ QVQEN 196_ QQANG 201_ HVSQD 206_ QEEPV 211_ YLESV 216_ ARVPA 221_ EDETQ 226_ SIDSE 231_ DSFVP 236_ GRRAS 241_ LSDLT 246_ DLEDI 251_ EGLTV 256_ RQLKE 261_ ILARN 266_ FVNYK 271_ GCCEK 276_ WELME 281_ RVTRL 286_ YKDQK 291_ GLQHL 296_ VSGAE 301_ DQNGG 306_ AVPSG 311_ LEENL 316_ CKICM 321_ DSPID 326_ CVLLE 331_ CGHMV 336_ TCTKC 341_ GKRMN 346_ ECPIC 351_ RQYVI 356_RAVHV
1: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling