Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)
1_MVAAH 6_ AAHSS 11_ SSAEW 16_ IACLD 21_ KRPLE 26_ RSSED 31_ VDIIF 36_ TRLKE 41_ VKAFE 46_ KFHPN 51_ LLHQI 56_ CLCGY 61_ YENLE 66_ KGITL 71_ FRQGD 76_ IGTNW 81_ YAVLA 86_ GSLDV 91_ KVSET 96_ SSHQD 101_ AVTIC 106_ TLGIG 111_ TAFGE 116_ SILDN 121_ TPRHA 126_ TIVTR 131_ ESSEL 136_ LRIEQ 141_ KDFKA 146_ LWEKY 151_ RQYMA 156_ GLLAP 161_ PYGVM 166_ ETGSN 171_ NDRIP 176_ DKENT 181_ PLIEP 186_ HVPLR 191_ PANTI 196_ TKVPS 201_ EKILR 206_ AGKIL 211_ RNAIL 216_ SRAPH 221_ MIRDR 226_ KYHLK 231_ TYRQC 236_ CVGTE 241_ LVDWM 246_ MQQTP 251_ CVHSR 256_ TQAVG 261_ MWQVL 266_ LEDGV 271_ LNHVD 276_ QEHHF 281_ QDKYL 286_ FYRFL 291_ DDEHE 296_ DAPLP 301_ TEEEK 306_ KECDE 311_ ELQDT 316_ MLLLS 321_ QMGPD 326_ AHMRM 331_ ILRKP 336_ PGQRT 341_ VDDLE 346_ IIYEE 351_ LLHIK 356_ ALSHL 361_ STTVK 366_ RELAG 371_ VLIFE 376_ SHAKG 381_ GTVLF 386_ NQGEE 391_ GTSWY 396_ IILKG 401_ SVNVV 406_ IYGKG 411_ VVCTL 416_ HEGDD 421_ FGKLA 426_ LVNDA 431_ PRAAS 436_ IVLRE 441_ DNCHF 446_ LRVDK 451_ EDFNR 456_ ILRDV 461_ EANTV 466_ RLKEH 471_ DQDVL 476_ VLEKV 481_ PAGNR 486_ ASNQG 491_ NSQPQ 496_ QKYTV 501_ MSGTP 506_ EKILE 511_ HFLET 516_ IRLEA 521_ TLNEA 526_ TDSVL 531_ NDFIM 536_ MHCVF 541_ MPNTQ 546_ LCPAL 551_ VAHYH 556_ AQPSQ 561_ GTEQE 566_ KMDYA 571_ LNNKR 576_ RVIRL 581_ VLQWA 586_ AMYGD 591_ LLQED 596_ DVSMA 601_ FLEEF 606_ YVSVS 611_ DDARM 616_ IAALK 621_ EQLPE 626_ LEKIV 631_ KQISE 636_ DAKAP 641_ QKKHK 646_ VLLQQ 651_ FNTGD 656_ ERAQK 661_ RQPIR 666_ GSDEV 671_ LFKVY 676_ CMDHT 681_ YTTIR 686_ VPVAT 691_ SVKEV 696_ ISAVA 701_ DKLGS 706_ GEGLI 711_ IVKMS 716_ SGGEK 721_ VVLKP 726_ NDVSV 731_ FTTLT 736_ INGRL 741_ FACPR 746_ EQFDS 751_ LTPLP 756_ EQEGP 761_ TVGTV 766_ GTFEL 771_ MSSKD 776_ LAYQM 781_ TIYDW 786_ ELFNC 791_ VHELE 796_ LIYHT 801_ FGRHN 806_ FKKTT 811_ ANLDL 816_ FLRRF 821_ NEIQF 826_ WVVTE 831_ ICLCS 836_ QLSKR 841_ VQLLK 846_ KFIKI 851_ AAHCK 856_ EYKNL 861_ NSFFA 866_ IVMGL 871_ SNVAV 876_ SRLAL 881_ TWEKL 886_ PSKFK 891_ KFYAE 896_ FESLM 901_ DPSRN 906_ HRAYR 911_ LTVAK 916_ LEPPL 921_ IPFMP 926_ LLIKD 931_ MTFTH 936_ EGNKT 941_ FIDNL 946_ VNFEK 951_ MRMIA 956_ NTART 961_ VRYYR 966_ SQPFN 971_ PDAAQ 976_ ANKNH 981_ QDVRS 986_ YVRQL 991_ NVIDN 996_ QRTLS 1001_ QMSHR 1006_LEPRR
1: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity)