Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)
1_MSPCG 6_ RARRQ 11_ TSRGA 16_ MAVLA 21_ WKFPR 26_ TRLPM 31_ GASAL 36_ CVVVL 41_ CWLYI 46_ FPVYR 51_ LPNEK 56_ EIVQG 61_ VLQQG 66_ TAWRR 71_ NQTAA 76_ RAFRK 81_ QMEDC 86_ CDPAH 91_ LFAMT 96_ KMNSP 101_ MGKSM 106_ WYDGE 111_ FLYSF 116_ TIDNS 121_ TYSLF 126_ PQATP 131_ FQLPL 136_ KKCAV 141_ VGNGG 146_ ILKKS 151_ GCGRQ 156_ IDEAN 161_ FVMRC 166_ NLPPL 171_ SSEYT 176_ KDVGS 181_ KSQLV 186_ TANPS 191_ IIRQR 196_ FQNLL 201_ WSRKT 206_ FVDNM 211_ KIYNH 216_ SYIYM 221_ PAFSM 226_ KTGTE 231_ PSLRV 236_ YYTLS 241_ DVGAN 246_ QTVLF 251_ ANPNF 256_ LRSIG 261_ KFWKS 266_ RGIHA 271_ KRLST 276_ GLFLV 281_ SAALG 286_ LCEEV 291_ AIYGF 296_ WPFSV 301_ NMHEQ 306_ PISHH 311_ YYDNV 316_ LPFSG 321_ FHAMP 326_ EEFLQ 331_ LWYLH 336_ KIGAL 341_ RMQLD 346_ PCEDT 351_SLQPT
1: Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubMed:18348864, PubMed:22885356, PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663). Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 (PubMed:8631981). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663). Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356)