CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.99.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)
1_MRSIR 6_ KRWTI 11_ CTISL 16_ LLIFY 21_ KTKEI 26_ ARTEE 31_ HQETQ 36_ LIGDG 41_ ELSLS 46_ RSLVN 51_ SSDKI 56_ IRKAG 61_ SSIFQ 66_ HNVEG 71_ WKINS 76_ SLVLE 81_ IRKNI 86_ LRFLD 91_ AERDV 96_ SVVKS 101_ SFKPG 106_ DVIHY 111_ VLDRR 116_ RTLNI 121_ SHDLH 126_ SLLPE 131_ VSPMK 136_ NRRFK 141_ TCAVV 146_ GNSGI 151_ LLDSE 156_ CGKEI 161_ DSHNF 166_ VIRCN 171_ LAPVV 176_ EFAAD 181_ VGTKS 186_ DFITM 191_ NPSVV 196_ QRAFG 201_ GFRNE 206_ SDREK 211_ FVHRL 216_ SMLND 221_ SVLWI 226_ PAFMV 231_ KGGEK 236_ HVEWV 241_ NALIL 246_ KNKLK 251_ VRTAY 256_ PSLRL 261_ IHAVR 266_ GYWLT 271_ NKVPI 276_ KRPST 281_ GLLMY 286_ TLATR 291_ FCDEI 296_ HLYGF 301_ WPFPK 306_ DLNGK 311_ AVKYH 316_ YYDDL 321_ KYRYF 326_ SNASP 331_ HRMPL 336_ EFKTL 341_ NVLHN 346_ RGALK 351_LTTGK
1: Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid (PubMed:9774483)