DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)
1_MAPKK 6_ RPETQ 11_ KTSEI 16_ VLRPR 21_ NKRSR 26_ SPLEL 31_ EPEAK 36_ KLCAK 41_ GSGPS 46_ RRCDS 51_ DCLWV 56_ GLAGP 61_ QILPP 66_ CRSIV 71_ RTLHQ 76_ HKLGR 81_ ASWPS 86_ VQQGL 91_ QQSFL 96_ HTLDS 101_ YRILQ 106_ KAAPF 111_ DRRAT 116_ SLAWH 121_ PTHPS 126_ TVAVG 131_ SKGGD 136_ IMLWN 141_ FGIKD 146_ KPTFI 151_ KGIGA 156_ GGSIT 161_ GLKFN 166_ PLNTN 171_ QFYAS 176_ SMEGT 181_ TRLQD 186_ FKGNI 191_ LRVFA 196_ SSDTI 201_ NIWFC 206_ SLDVS 211_ ASSRM 216_ VVTGD 221_ NVGNV 226_ ILLNM 231_ DGKEL 236_ WNLRM 241_ HKKKV 246_ THVAL 251_ NPCCD 256_ WFLAT 261_ ASVDQ 266_ TVKIW 271_ DLRQV 276_ RGKAS 281_ FLYSL 286_ PHRHP 291_ VNAAC 296_ FSPDG 301_ ARLLT 306_ TDQKS 311_ EIRVY 316_ SASQW 321_ DCPLG 326_ LIPHP 331_ HRHFQ 336_ HLTPI 341_ KAAWH 346_ PRYNL 351_ IVVGR 356_ YPDPN 361_ FKSCT 366_ PYELR 371_ TIDVF 376_ DGNSG 381_ KMMCQ 386_ LYDPE 391_ SSGIS 396_ SLNEF 401_ NPMGD 406_ TLASA 411_ MGYHI 416_ LIWSQ 421_EEART
1: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:32789493, PubMed:9892649). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:14751237, PubMed:16260596, PubMed:32789493). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:12944386, PubMed:16260596). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16473935, PubMed:16678110). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16473935, PubMed:16678110). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825)
2: Inhibits UV-damaged DNA repair
3: Inhibits UV-damaged DNA repair