Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta)
1_MHSPP 6_ RDQAA 11_ IMLWK 16_ LVENV 21_ KYEDI 26_ YEDRH 31_ DGVPS 36_ HSSRL 41_ SQLGS 46_ VSQGP 51_ YSSAP 56_ PLSHT 61_ PSSDF 66_ QPPYF 71_ PPPYQ 76_ PLPYH 81_ QSQDP 86_ YSHVN 91_ DPYSL 96_ NPLHQ 101_ PQQHP 106_ WGQRQ 111_ RQEVG 116_ SEAGS 121_ LLPQP 126_ RAALP 131_ QLSGL 136_ DPRRD 141_ YHSVR 146_ RPDVL 151_ LHSAH 156_ HGLDA 161_ GMGDS 166_ LSLHG 171_ LGHPG 176_ MEDVQ 181_ SVEDA 186_ NNSGM 191_ NLLDQ 196_ SVIKK 201_ VPVPP 206_ KSVTS 211_ LMMNK 216_ DGFLG 221_ GMSVN 226_ TGEVF 231_ CSVPG 236_ RLSLL 241_ SSTSK 246_ YKVTV 251_ GEVQR 256_ RLSPP 261_ ECLNA 266_ SLLGG 271_ VLRRA 276_ KSKNG 281_ GRSLR 286_ ERLEK 291_ IGLNL 296_ PAGRR 301_ KAANV 306_ TLLTS 311_ LVEGE 316_ AVHLA 321_ RDFGY 326_ ICETE 331_ FPAKA 336_ VSEYL 341_ NRQHT 346_ DPSDL 351_ HSRKN 356_ MLLAT 361_ KQLCK 366_ EFTDL 371_ LAQDR 376_ TPIGN 381_ SRPSP 386_ ILEPG 391_ IQSCL 396_ THFSL 401_ ITHGF 406_ GAPAI 411_ CAALT 416_ ALQNY 421_ LTEAL 426_ KGMDK 431_ MFLNN 436_ TTTNR 441_ HTSGE 446_ GPGSK 451_TGDKE
1: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia