Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)
1_MGRQK 6_ ELVSR 11_ CGEML 16_ HIRYR 21_ LLRQA 26_ LAECL 31_ GTLIL 36_ VMFGC 41_ GSVAQ 46_ VVLSR 51_ GTHGG 56_ FLTIN 61_ LAFGF 66_ AVTLG 71_ ILIAG 76_ QVSGA 81_ HLNPA 86_ VTFAM 91_ CFLAR 96_ EPWIK 101_ LPIYT 106_ LAQTL 111_ GAFLG 116_ AGIVF 121_ GLYYD 126_ AIWHF 131_ ADNQL 136_ FVSGP 141_ NGTAG 146_ IFATY 151_ PSGHL 156_ DMING 161_ FFDQF 166_ IGTAS 171_ LIVCV 176_ LAIVD 181_ PYNNP 186_ VPRGL 191_ EAFTV 196_ GLVVL 201_ VIGTS 206_ MGFNS 211_ GYAVN 216_ PARDF 221_ GPRLF 226_ TALAG 231_ WGSAV 236_ FTTGQ 241_ HWWWV 246_ PIVSP 251_ LLGSI 256_ AGVFV 261_ YQLMI 266_ GCHLE 271_ QPPPS 276_ NEEEN 281_ VKLAH 286_VKHKE
1: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:12239222, PubMed:30420639). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (PubMed:20724658). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (By similarity). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity)