Acid sphingomyelinase-like phosphodiesterase 3a (ASM-like phosphodiesterase 3a) (EC 3.1.4.-)
1_MALVR 6_ ALVCC 11_ LLTAW 16_ HCRSG 21_ LGLPV 26_ APAGG 31_ RNPPP 36_ AIGQF 41_ WHVTD 46_ LHLDP 51_ TYHIT 56_ DDHTK 61_ VCASS 66_ KGANA 71_ SNPGP 76_ FGDVL 81_ CDSPY 86_ QLILS 91_ AFDFI 96_ KNSGQ 101_ EASFM 106_ IWTGD 111_ SPPHV 116_ PVPEL 121_ STDTV 126_ INVIT 131_ NMTTT 136_ IQSLF 141_ PNLQV 146_ FPALG 151_ NHDYW 156_ PQDQL 161_ PVVTS 166_ KVYNA 171_ VANLW 176_ KPWLD 181_ EEAIS 186_ TLRKG 191_ GFYSQ 196_ KVTTN 201_ PNLRI 206_ ISLNT 211_ NLYYG 216_ PNIMT 221_ LNKTD 226_ PANQF 231_ EWLES 236_ TLNNS 241_ QQNKE 246_ KVYII 251_ AHVPV 256_ GYLPS 261_ SQNIT 266_ AMREY 271_ YNEKL 276_ IDIFQ 281_ KYSDV 286_ IAGQF 291_ YGHTH 296_ RDSIM 301_ VLSDK 306_ KGSPV 311_ NSLFV 316_ APAVT 321_ PVKSV 326_ LEKQT 331_ NNPGI 336_ RLFQY 341_ DPRDY 346_ KLLDM 351_ LQYYL 356_ NLTEA 361_ NLKGE 366_ SIWKL 371_ EYILT 376_ QTYDI 381_ EDLQP 386_ ESLYG 391_ LAKQF 396_ TILDS 401_ KQFIK 406_ YYNYF 411_ FVSYD 416_ SSVTC 421_ DKTCK 426_ AFQIC 431_ AIMNL 436_ DNISY 441_ ADCLK 446_QLYIK
1: Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling (PubMed:37890481). Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA (PubMed:37890481). Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:25288789, PubMed:26783088). Has in vitro activity with p-nitrophenyl-TMP (PubMed:25288789). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (PubMed:25288789, PubMed:26783088, PubMed:28104755). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine (PubMed:26783088). Does not have sphingomyelin phosphodiesterase activity (PubMed:25288789, PubMed:26783088)