Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)
1_MRLLA 6_ WLIFL 11_ ANWGG 16_ ARAEP 21_ GKFWH 26_ IADLH 31_ LDPDY 36_ KVSKD 41_ PFQVC 46_ PSAGS 51_ QPVPD 56_ AGPWG 61_ DYLCD 66_ SPWAL 71_ INSSI 76_ YAMKE 81_ IEPEP 86_ DFILW 91_ TGDDT 96_ PHVPD 101_ EKLGE 106_ AAVLE 111_ IVERL 116_ TKLIR 121_ EVFPD 126_ TKVYA 131_ ALGNH 136_ DFHPK 141_ NQFPA 146_ GSNNI 151_ YNQIA 156_ ELWKP 161_ WLSNE 166_ SIALF 171_ KKGAF 176_ YCEKL 181_ PGPSG 186_ AGRIV 191_ VLNTN 196_ LYYTS 201_ NALTA 206_ DMADP 211_ GQQFQ 216_ WLEDV 221_ LTDAS 226_ KAGDM 231_ VYIVG 236_ HVPPG 241_ FFEKT 246_ QNKAW 251_ FREGF 256_ NEKYL 261_ KVVRK 266_ HHRVI 271_ AGQFF 276_ GHHHT 281_ DSFRM 286_ LYDDA 291_ GVPIS 296_ AMFIT 301_ PGVTP 306_ WKTTL 311_ PGVVN 316_ GANNP 321_ AIRVF 326_ EYDRA 331_ TLSLK 336_ DMVTY 341_ FMNLS 346_ QANAQ 351_ GTPRW 356_ ELEYQ 361_ LTEAY 366_ GVPDA 371_ SAHSM 376_ HTVLD 381_ RIAGD 386_ QSTLQ 391_ RYYVY 396_ NSVSY 401_ SAGVC 406_ DEACS 411_ MQHVC 416_ AMRQV 421_ DIDAY 426_ TTCLY 431_ ASGTT 436_ PVPQL 441_ PLLLM 446_ALLGL
1: Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity)