ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)
1_MAAFS 6_ EMGVM 11_ PEIAQ 16_ AVEEM 21_ DWLLP 26_ TDIQA 31_ ESIPL 36_ ILGGG 41_ DVLMA 46_ AETGS 51_ GKTGA 56_ FSIPV 61_ IQIVY 66_ ETLKD 71_ QQEGK 76_ KGKTT 81_ IKTGA 86_ SVLNK 91_ WQMNP 96_ YDRGS 101_ AFAIG 106_ SDGLC 111_ CQSRE 116_ VKEWH 121_ GCRAT 126_ KGLMK 131_ GKHYY 136_ EVSCH 141_ DQGLC 146_ RVGWS 151_ TMQAS 156_ LDLGT 161_ DKFGF 166_ GFGGT 171_ GKKSH 176_ NKQFD 181_ NYGEE 186_ FTMHD 191_ TIGCY 196_ LDIDK 201_ GHVKF 206_ SKNGK 211_ DLGLA 216_ FEIPP 221_ HMKNQ 226_ ALFPA 231_ CVLKN 236_ AELKF 241_ NFGEE 246_ EFKFP 251_ PKDGF 256_ VALSK 261_ APDGY 266_ IVKSQ 271_ HSGNA 276_ QVTQT 281_ KFLPN 286_ APKAL 291_ IVEPS 296_ RELAE 301_ QTLNN 306_ IKQFK 311_ KYIDN 316_ PKLRE 321_ LLIIG 326_ GVAAR 331_ DQLSV 336_ LENGV 341_ DIVVG 346_ TPGRL 351_ DDLVS 356_ TGKLN 361_ LSQVR 366_ FLVLD 371_ EADGL 376_ LSQGY 381_ SDFIN 386_ RMHNQ 391_ IPQVT 396_ SDGKR 401_ LQVIV 406_ CSATL 411_ HSFDV 416_ KKLSE 421_ KIMHF 426_ PTWVD 431_ LKGED 436_ SVPDT 441_ VHHVV 446_ VPVNP 451_ KTDRL 456_ WERLG 461_ KSHIR 466_ TDDVH 471_ AKDNT 476_ RPGAN 481_ SPEMW 486_ SEAIK 491_ ILKGE 496_ YAVRA 501_ IKEHK 506_ MDQAI 511_ IFCRT 516_ KIDCD 521_ NLEQY 526_ FIQQG 531_ GGPDK 536_ KGHQF 541_ SCVCL 546_ HGDRK 551_ PHERK 556_ QNLER 561_ FKKGD 566_ VRFLI 571_ CTDVA 576_ ARGID 581_ IHGVP 586_ YVINV 591_ TLPDE 596_ KQNYV 601_ HRIGR 606_ VGRAE 611_ RMGLA 616_ ISLVA 621_ TEKEK 626_ VWYHV 631_ CSSRG 636_ KGCYN 641_ TRLKE 646_ DGGCT 651_ IWYNE 656_ MQLLS 661_ EIEEH 666_ LNCTI 671_ SQVEP 676_ DIKVP 681_ VDEFD 686_ GKVTY 691_ GQKRA 696_ AGGGS 701_ YKGHV 706_ DILAP 711_ TVQEL 716_ AALEK 721_ EAQTS 726_ FLHLG 731_YLPNQ
1: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity)
2: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs
3: (Microbial infection) Required for Coronavirus IBV replication