Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)
1_MARGL 6_ GAPHW 11_ VAVGL 16_ LTWAT 21_ LGLLV 26_ AGLGG 31_ HDDLH 36_ DDLQE 41_ DFHGH 46_ SHRHS 51_ HEDFH 56_ HGHSH 61_ AHGHG 66_ HTHES 71_ IWHGH 76_ THDHD 81_ HGHSH 86_ EDLHH 91_ GHSHG 96_ YSHES 101_ LYHRG 106_ HGHDH 111_ EHSHG 116_ GYGES 121_ GAPGI 126_ KQDLD 131_ AVTLW 136_ AYALG 141_ ATVLI 146_ SAAPF 151_ FVLFL 156_ IPVES 161_ NSPRH 166_ RSLLQ 171_ ILLSF 176_ ASGGL 181_ LGDAF 186_ LHLIP 191_ HALEP 196_ HSHHT 201_ LEQPG 206_ HGHSH 211_ SGQGP 216_ ILSVG 221_ LWVLS 226_ GIVAF 231_ LVVEK 236_ FVRHV 241_ KGGHG 246_ HSHGH 251_ GHAHS 256_ HTRGS 261_ HGHGR 266_ QERST 271_ KEKQS 276_ SEEEE 281_ KETRG 286_ VQKRR 291_ GGSTV 296_ PKDGP 301_ VRPQN 306_ AEEEK 311_ RGLDL 316_ RVSGY 321_ LNLAA 326_ DLAHN 331_ FTDGL 336_ AIGAS 341_ FRGGR 346_ GLGIL 351_ TTMTV 356_ LLHEV 361_ PHEVG 366_ DFAIL 371_ VQSGC 376_ SKKQA 381_ MRLQL 386_ LTAVG 391_ ALAGT 396_ ACALL 401_ TEGGA 406_ VGSEI 411_ AGGAG 416_ PGWVL 421_ PFTAG 426_ GFIYV 431_ ATVSV 436_ LPELL 441_ REASP 446_ LQSLL 451_ EVLGL 456_ LGGVI 461_MMVLI
1: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:22317921, PubMed:28205653, PubMed:29980658). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508)