Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)
1_MEPHV 6_ LGAVL 11_ YWLLL 16_ PCALL 21_ AACLL 26_ RFSGL 31_ SLVYL 36_ LFLLL 41_ LPWFP 46_ GPTRC 51_ GLQGH 56_ TGRLL 61_ RALLG 66_ LSLLF 71_ LVAHL 76_ ALQIC 81_ LHIVP 86_ RLDQL 91_ LGPSC 96_ SRWET 101_ LSRHI 106_ GVTRL 111_ DLKDI 116_ PNAIR 121_ LVAPD 126_ LGILV 131_ VSSVC 136_ LGICG 141_ RLARN 146_ TRQSP 151_ HPREL 156_ DDDER 161_ DVDAS 166_ PTAGL 171_ QEAAT 176_ LAPTR 181_ RSRLA 186_ ARFRV 191_ TAHWL 196_ LVAAG 201_ RVLAV 206_ TLLAL 211_ AGIAH 216_ PSALS 221_ SVYLL 226_ LFLAL 231_ CTWWA 236_ CHFPI 241_ STRGF 246_ SRLCV 251_ AVGCF 256_ GAGHL 261_ ICLYC 266_ YQMPL 271_ AQALL 276_ PPAGI 281_ WARVL 286_ GLKDF 291_ VGPTN 296_ CSSPH 301_ ALVLN 306_ TGLDW 311_ PVYAS 316_ PGVLL 321_ LLCYA 326_ TASLR 331_ KLRAY 336_ RPSGQ 341_ RKEAA 346_ KGYEA 351_ RELEL 356_ AELDQ 361_ WPQER 366_ ESDQH 371_ VVPTA 376_ PDTEA 381_ DNCIV 386_ HELTG 391_ QSSVL 396_ RRPVR 401_ PKRAE 406_ PREAS 411_ PLHSL 416_ GHLIM 421_ DQSYV 426_ CALIA 431_ MMVWS 436_ ITYHS 441_ WLTFV 446_ LLLWA 451_ CLIWT 456_ VRSRH 461_ QLAML 466_ CSPCI 471_ LLYGM 476_ TLCCL 481_ RYVWA 486_ MDLRP 491_ ELPTT 496_ LGPVS 501_ LRQLG 506_ LEHTR 511_ YPCLD 516_ LGAML 521_ LYTLT 526_ FWLLL 531_ RQFVK 536_ EKLLK 541_ WAESP 546_ AALTE 551_ VTVAD 556_ TEPTR 561_ TQTLL 566_ QSLGE 571_ LVKGV 576_ YAKYW 581_ IYVCA 586_ GMFIV 591_ VSFAG 596_ RLVVY 601_ KIVYM 606_ FLFLL 611_ CLTLF 616_ QVYYS 621_ LWRKL 626_ LKAFW 631_ WLVVA 636_ YTMLV 641_ LIAVY 646_ TFQFQ 651_ DFPAY 656_ WRNLT 661_ GFTDE 666_ QLGDL 671_ GLEQF 676_ SVSEL 681_ FSSIL 686_ VPGFF 691_ LLACI 696_ LQLHY 701_ FHRPF 706_ MQLTD 711_ MEHVS 716_ LPGTR 721_ LPRWA 726_ HRQDA 731_ VSGTP 736_ LLREE 741_ QQEHQ 746_ QQQQE 751_ EEEEE 756_ EDSRD 761_ EGLGV 766_ ATPHQ 771_ ATQVP 776_ EGAAK 781_ WGLVA 786_ ERLLE 791_ LAAGF 796_ SDVLS 801_ RVQVF 806_ LRRLL 811_ ELHVF 816_ KLVAL 821_ YTVWV 826_ ALKEV 831_ SVMNL 836_ LLVVL 841_ WAFAL 846_ PYPRF 851_ RPMAS 856_ CLSTV 861_ WTCVI 866_ IVCKM 871_ LYQLK 876_ VVNPQ 881_ EYSSN 886_ CTEPF 891_ PNSTN 896_ LLPTE 901_ ISQSL 906_ LYRGP 911_ VDPAN 916_ WFGVR 921_ KGFPN 926_ LGYIQ 931_ NHLQV 936_ LLLLV 941_ FEAIV 946_ YRRQE 951_ HYRRQ 956_ HQLAP 961_ LPAQA 966_ VFASG 971_ TRQQL 976_ DQDLL 981_ GCLKY 986_ FINFF 991_ FYKFG 996_ LEICF 1001_ LMAVN 1006_ VIGQR 1011_ MNFLV 1016_ TLHGC 1021_ WLVAI 1026_ LTRRH 1031_ RQAIA 1036_ RLWPN 1041_ YCLFL 1046_ ALFLL 1051_ YQYLL 1056_ CLGMP 1061_ PALCI 1066_ DYPWR 1071_ WSRAV 1076_ PMNSA 1081_ LIKWL 1086_ YLPDF 1091_ FRAPN 1096_ STNLI 1101_ SDFLL 1106_ LLCAS 1111_ QQWQV 1116_ FSAER 1121_ TEEWQ 1126_ RMAGV 1131_ NTDRL 1136_ EPLRG 1141_ EPNPV 1146_ PNFIH 1151_ CRSYL 1156_ DMLKV 1161_ AVFRY 1166_ LFWLV 1171_ LVVVF 1176_ VTGAT 1181_ RISIF 1186_ GLGYL 1191_ LACFY 1196_ LLLFG 1201_ TALLQ 1206_ RDTRA 1211_ RLVLW 1216_ DCLIL 1221_ YNVTV 1226_ IISKN 1231_ MLSLL 1236_ ACVFV 1241_ EQMQT 1246_ GFCWV 1251_ IQLFS 1256_ LVCTV 1261_ KGYYD 1266_ PKEMM 1271_ DRDQD 1276_ CLLPV 1281_ EEAGI 1286_ IWDSV 1291_ CFFFL 1296_ LLQRR 1301_ VFLSH 1306_ YYLHV 1311_ RADLQ 1316_ ATALL 1321_ ASRGF 1326_ ALYNA 1331_ ANLKS 1336_ IDFHR 1341_ RIEEK 1346_ SLAQL 1351_ KRQME 1356_ RIRAK 1361_ QEKHR 1366_ QGRVD 1371_ RSRPQ 1376_ DTLGP 1381_ KDPGL 1386_ EPGPD 1391_ SPGGS 1396_ SPPRR 1401_ QWWRP 1406_ WLDHA 1411_ TVIHS 1416_ GDYFL 1421_ FESDS 1426_ EEEEE 1431_ AVPED 1436_ PRPSA 1441_ QSAFQ 1446_ LAYQA 1451_ WVTNA 1456_ QAVLR 1461_ RRQQE 1466_ QEQAR 1471_ QEQAG 1476_ QLPTG 1481_ GGPSQ 1486_ EVEPA 1491_ EGPEE 1496_ AAAGR 1501_ SHVVQ 1506_ RVLST 1511_ AQFLW 1516_ MLGQA 1521_ LVDEL 1526_ TRWLQ 1531_ EFTRH 1536_ HGTMS 1541_ DVLRA 1546_ ERYLL 1551_ TQELL 1556_ QGGEV 1561_ HRGVL 1566_ DQLYT 1571_ SQAEA 1576_ TLPGP 1581_ TEAPN 1586_ APSTV 1591_ SSGLG 1596_ AEEPL 1601_ SSMTD 1606_ DMGSP 1611_ LSTGY 1616_ HTRSG 1621_ SEEAV 1626_ TDPGE 1631_ REAGA 1636_ SLYQG 1641_ LMRTA 1646_ SELLL 1651_ DRRLR 1656_ IPELE 1661_ EAELF 1666_ AEGQG 1671_ RALRL 1676_ LRAVY 1681_ QCVAA 1686_ HSELL 1691_ CYFII 1696_ ILNHM 1701_ VTASA 1706_ GSLVL 1711_ PVLVF 1716_ LWAML 1721_ SIPRP 1726_ SKRFW 1731_ MTAIV 1736_ FTEIA 1741_ VVVKY 1746_ LFQFG 1751_ FFPWN 1756_ SHVVL 1761_ RRYEN 1766_ KPYFP 1771_ PRILG 1776_ LEKTD 1781_ GYIKY 1786_ DLVQL 1791_ MALFF 1796_ HRSQL 1801_ LCYGL 1806_ WDHEE 1811_ DSPSK 1816_ EHDKS 1821_ GEEEQ 1826_ GAEEG 1831_ PGVPA 1836_ ATTED 1841_ HIQVE 1846_ ARVGP 1851_ TDGTP 1856_ EPQVE 1861_ LRPRD 1866_ TRRIS 1871_ LRFRR 1876_ RKKEG 1881_ PARKG 1886_ AAAIE 1891_ AEDRE 1896_ EEEGE 1901_ EEKEA 1906_ PTGRE 1911_ KRPSR 1916_ SGGRV 1921_ RAAGR 1926_ RLQGF 1931_ CLSLA 1936_ QGTYR 1941_ PLRRF 1946_ FHDIL 1951_ HTKYR 1956_ AATDV 1961_ YALMF 1966_ LADVV 1971_ DFIII 1976_ IFGFW 1981_ AFGKH 1986_ SAATD 1991_ ITSSL 1996_ SDDQV 2001_ PEAFL 2006_ VMLLI 2011_ QFSTM 2016_ VVDRA 2021_ LYLRK 2026_ TVLGK 2031_ LAFQV 2036_ ALVLA 2041_ IHLWM 2046_ FFILP 2051_ AVTER 2056_ MFNQN 2061_ VVAQL 2066_ WYFVK 2071_ CIYFA 2076_ LSAYQ 2081_ IRCGY 2086_ PTRIL 2091_ GNFLT 2096_ KKYNH 2101_ LNLFL 2106_ FQGFR 2111_ LVPFL 2116_ VELRA 2121_ VMDWV 2126_ WTDTT 2131_ LSLSS 2136_ WMCVE 2141_ DIYAN 2146_ IFIIK 2151_ CSRET 2156_ EKKYP 2161_ QPKGQ 2166_ KKKKI 2171_ VKYGM 2176_ GGLII 2181_ LFLIA 2186_ IIWFP 2191_ LLFMS 2196_ LVRSV 2201_ VGVVN 2206_ QPIDV 2211_ TVTLK 2216_ LGGYE 2221_ PLFTM 2226_ SAQQP 2231_ SIIPF 2236_ TAQAY 2241_ EELSR 2246_ QFDPQ 2251_ PLAMQ 2256_ FISQY 2261_ SPEDI 2266_ VTAQI 2271_ EGSSG 2276_ ALWRI 2281_ SPPSR 2286_ AQMKR 2291_ ELYNG 2296_ TADIT 2301_ LRFTW 2306_ NFQRD 2311_ LAKGG 2316_ TVEYA 2321_ NEKHM 2326_ LALAP 2331_ NSTAR 2336_ RQLAS 2341_ LLEGT 2346_ SDQSV 2351_ VIPNL 2356_ FPKYI 2361_ RAPNG 2366_ PEANP 2371_ VKQLQ 2376_ PNEEA 2381_ DYLGV 2386_ RIQLR 2391_ REQGA 2396_ GATGF 2401_ LEWWV 2406_ IELQE 2411_ CRTDC 2416_ NLLPM 2421_ VIFSD 2426_ KVSPP 2431_ SLGFL 2436_ AGYGI 2441_ MGLYV 2446_ SIVLV 2451_ IGKFV 2456_ RGFFS 2461_ EISHS 2466_ IMFEE 2471_ LPCVD 2476_ RILKL 2481_ CQDIF 2486_ LVRET 2491_ RELEL 2496_ EEELY 2501_ AKLIF 2506_ LYRSP 2511_ ETMIK 2516_WTREK
1: Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007)