Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
1_MEARE 6_ PGRPT 11_ PTYHL 16_ VPNTS 21_ QSQVE 26_ EDVSS 31_ PPQRS 36_ SETMQ 41_ LKKEI 46_ SLLNG 51_ VSLVV 56_ GNMIG 61_ SGIFV 66_ SPKGV 71_ LVHTA 76_ SYGMS 81_ LIVWA 86_ IGGLF 91_ SVVGA 96_ LCYAE 101_ LGTTI 106_ TKSGA 111_ SYAYI 116_ LEAFG 121_ GFIAF 126_ IRLWV 131_ SLLVV 136_ EPTGQ 141_ AIIAI 146_ TFANY 151_ IIQPS 156_ FPSCD 161_ PPYLA 166_ CRLLA 171_ AACIC 176_ LLTFV 181_ NCAYV 186_ KWGTR 191_ VQDTF 196_ TYAKV 201_ VALIA 206_ IIVMG 211_ LVKLC 216_ QGHSE 221_ HFQDA 226_ FEGSS 231_ WDMGN 236_ LSLAL 241_ YSALF 246_ SYSGW 251_ DTLNF 256_ VTEEI 261_ KNPER 266_ NLPLA 271_ IGISM 276_ PIVTL 281_ IYILT 286_ NVAYY 291_ TVLNI 296_ SDVLS 301_ SDAVA 306_ VTFAD 311_ QTFGM 316_ FSWTI 321_ PIAVA 326_ LSCFG 331_ GLNAS 336_ IFASS 341_ RLFFV 346_ GSREG 351_ HLPDL 356_ LSMIH 361_ IERFT 366_ PIPAL 371_ LFNCT 376_ MALIY 381_ LIVED 386_ VFQLI 391_ NYFSF 396_ SYWFF 401_ VGLSV 406_ VGQLY 411_ LRWKE 416_ PKRPR 421_ PLKLS 426_ VFFPI 431_ VFCIC 436_ SVFLV 441_ IVPLF 446_ TDTIN 451_ SLIGI 456_ GIALS 461_ GVPFY 466_ FMGVY 471_ LPESR 476_ RPLFI 481_ RNVLA 486_ AITRG 491_ TQQLC 496_ FCVLT 501_ ELDVA 506_EEKKD
1: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity)