Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)
1_MVDKN 6_ IYIIQ 11_ GEINI 16_ VVGAI 21_ KRNAR 26_ WSTHT 31_ PLDEE 36_ RDPLL 41_ HSFGH 46_ LKEVL 51_ NSITE 56_ LSEIE 61_ PNVFL 66_ RPFLE 71_ VIRSE 76_ DTTGP 81_ ITGLA 86_ LTSVN 91_ KFLSY 96_ ALIDP 101_ THEGT 106_ AEGME 111_ NMADA 116_ VTHAR 121_ FVGTD 126_ PASDE 131_ VVLMK 136_ ILQVL 141_ RTLLL 146_ TPVGA 151_ HLTNE 156_ SVCEI 161_ MQSCF 166_ RICFE 171_ MRLSE 176_ LLRKS 181_ AEHTL 186_ VDMVQ 191_ LLFTR 196_ LPQFK 201_ EEPKN 206_ YVGTN 211_ MKKLK 216_ MRAGG 221_ MSDSS 226_ KWKKQ 231_ KRSPR 236_ PPRHM 241_ TKVTP 246_ GSELP 251_ TPNGT 256_ TLSSN 261_ LTGGM 266_ PFIDV 271_ PTPIS 276_ SASSE 281_ AASAV 286_ VSPST 291_ DSGLE 296_ FSSQT 301_ TSKED 306_ LTDLE 311_ QPGSP 316_ GYSTA 321_ TEPGS 326_ SELGV 331_ PEQPD 336_ LQEGT 341_ HVEKS 346_ QSASV 351_ ESIPE 356_ VLEEC 361_ TSPAD 366_ HSDSA 371_ SVHDM 376_ DYVNP 381_ RGVRF 386_ TQSSQ 391_ KEGTA 396_ LVPYG 401_ LPCIR 406_ ELFRF 411_ LISLT 416_ NPHDR 421_ HNSEV 426_ MIHMG 431_ LHLLT 436_ VALES 441_ APVAQ 446_ CQTLL 451_ GLIKD 456_ EMCRH 461_ LFQLL 466_ SIERL 471_ NLYAA 476_ SLRVC 481_ FLLFE 486_ SMREH 491_ LKFQM 496_ EMYIK 501_ KLMEI 506_ ITVEN 511_ PKMPY 516_ EMKEM 521_ ALEAI 526_ VQLWR 531_ IPSFV 536_ TELYI 541_ NYDCD 546_ YYCSN 551_ LFEEL 556_ TKLLS 561_ KNAFP 566_ VSGQL 571_ YTTHL 576_ LSLDA 581_ LLTVI 586_ DSTEA 591_ HCQAK 596_ VLNSL 601_ TQQEK 606_ KETAR 611_ PSCEI 616_ VDGTR 621_ EASNT 626_ ERTAS 631_ DGKAV 636_ GMASD 641_ IPGLH 646_ LPGGG 651_ RLPPE 656_ HGKSG 661_ CSDLE 666_ EAVDS 671_ GADKK 676_ FARKP 681_ PRFSC 686_ LLPDP 691_ RELIE 696_ IKNKK 701_ KLLIT 706_ GTEQF 711_ NQKPK 716_ KGIQF 721_ LQEKG 726_ LLTIP 731_ MDNTE 736_ VAQWL 741_ RENPR 746_ LDKKM 751_ IGEFV 756_ SDRKN 761_ IDLLE 766_ SFVST 771_ FSFQG 776_ LRLDE 781_ ALRLY 786_ LEAFR 791_ LPGEA 796_ PVIQR 801_ LLEAF 806_ TERWM 811_ NCNGS 816_ PFANS 821_ DACFS 826_ LAYAV 831_ IMLNT 836_ DQHNH 841_ NVRKQ 846_ NAPMT 851_ LEEFR 856_ KNLKG 861_ VNGGK 866_ DFEQD 871_ ILEDM 876_ YHAIK 881_ NEEIV 886_ MPEEQ 891_ TGLVR 896_ ENYVW 901_ NVLLH 906_ RGATP 911_ EGIFL 916_ RVPTA 921_ SYDLD 926_ LFTMT 931_ WGPTI 936_ AALSY 941_ VFDKS 946_ LEETI 951_ IQKAI 956_ SGFRK 961_ CAMIS 966_ AHYGL 971_ SDVFD 976_ NLIIS 981_ LCKFT 986_ ALSSE 991_ SIENL 996_ PSVFG 1001_ SNPKA 1006_ HIAAK 1011_ TVFHL 1016_ AHRHG 1021_ DILRE 1026_ GWKNI 1031_ MEAML 1036_ QLFRA 1041_ QLLPK 1046_ AMIEV 1051_ EDFVD 1056_ PNGKI 1061_ SLQRE 1066_ ETPSN 1071_ RGEST 1076_ VLSFV 1081_ SWLTL 1086_ SGPEQ 1091_ SSVRG 1096_ PSTEN 1101_ QEAKR 1106_ VALEC 1111_ IKQCD 1116_ PEKMI 1121_ TESKF 1126_ LQLES 1131_ LQELM 1136_ KALVS 1141_ VTPDE 1146_ ETYDE 1151_ EDAAF 1156_ CLEML 1161_ LRIVL 1166_ ENRDR 1171_ VGCVW 1176_ QTVRD 1181_ HLYHL 1186_ CVQAQ 1191_ DFCFL 1196_ VERAV 1201_ VGLLR 1206_ LAIRL 1211_ LRREE 1216_ ISAQV 1221_ LLSLR 1226_ ILLLM 1231_ KPSVL 1236_ SRVSH 1241_ QVAYG 1246_ LHELL 1251_ KTNAA 1256_ NIHSG 1261_ DDWAT 1266_ LFTLL 1271_ ECIGS 1276_ GVKPP 1281_ AALQA 1286_ TARAD 1291_ APDAG 1296_ AQSDS 1301_ ELPSY 1306_ HQNDV 1311_ SLDRG 1316_ YTSDS 1321_ EVYTD 1326_ HGRPG 1331_ KIHRS 1336_ ATDAD 1341_ VVNSG 1346_ WLVVG 1351_ KDDVD 1356_ NSKPG 1361_ PSRPG 1366_ PSPLI 1371_ NQYSL 1376_ TVGLD 1381_ LGPHD 1386_ TKSLL 1391_ KCVES 1396_ LSFIV 1401_ RDAAH 1406_ ITPDN 1411_ FELCV 1416_ KTLRI 1421_ FVEAS 1426_ LNGGC 1431_ KSQEK 1436_ RGKSH 1441_ KYDSK 1446_ GNRFK 1451_ KKSKE 1456_ GSMLR 1461_ RPRTS 1466_ SQHAS 1471_ RGGQS 1476_ DDDED 1481_ EGVPA 1486_ SYHTV 1491_ SLQVS 1496_ QDLLD 1501_ LMHTL 1506_ HTRAA 1511_ SIYSS 1516_ WAEEQ 1521_ RHLET 1526_ GGQKI 1531_ EADSR 1536_ TLWAH 1541_ CWCPL 1546_ LQGIA 1551_ CLCCD 1556_ ARRQV 1561_ RMQAL 1566_ TYLQR 1571_ ALLVH 1576_ DLQKL 1581_ DALEW 1586_ ESCFN 1591_ KVLFP 1596_ LLTKL 1601_ LENIS 1606_ PADVG 1611_ GMEET 1616_ RMRAS 1621_ TLLSK 1626_ VFLQH 1631_ LSPLL 1636_ SLSTF 1641_ AALWL 1646_ TILDF 1651_ MDKYM 1656_ HAGSS 1661_ DLLSE 1666_ AIPES 1671_ LKNML 1676_ LVMDT 1681_ AEIFH 1686_ SADAR 1691_ GGGPS 1696_ ALWEI 1701_ TWERI 1706_ DCFLP 1711_ HLRDE 1716_ LFKQT 1721_ VIQDP 1726_ MPMEP 1731_ QGQKP 1736_ LASAH 1741_ LTSAA 1746_ GDTRT 1751_ PGHPP 1756_ PPEIP 1761_ SELGA 1766_ CDFEK 1771_ PESPR 1776_ AASSS 1781_ SPGSP 1786_ VASSP 1791_ SRLSP 1796_ TPDGP 1801_ PPLAQ 1806_ PPLIL 1811_ QPLAS 1816_ PLQVG 1821_ VPPMT 1826_ LPIIL 1831_ NPALI 1836_ EATSP 1841_ VPLLA 1846_ TPRPT 1851_DPIPT
1: Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516)