Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2)
1_MNYVG 6_ QLAGQ 11_ VIVTV 16_ KELYK 21_ GINQA 26_ TLSGC 31_ IDVIV 36_ VQQQD 41_ GSYQC 46_ SPFHV 51_ RFGKL 56_ GVLRS 61_ KEKVI 66_ DIEIN 71_ GSAVD 76_ LHMKL 81_ GDNGE 86_ AFFVE 91_ ETEEE 96_ YEKLP 101_ AYLAT 106_ SPIPT 111_ EDQFF 116_ KDIDT 121_ PLVKS 126_ GGDET 131_ PSQSS 136_ DISHV 141_ LETET 146_ IFTPS 151_ SVKKK 156_ KRRRK 161_ KYKQD 166_ SKKEE 171_ QAASA 176_ AAEDT 181_ CDVGV 186_ SSDDD 191_ KGAQA 196_ ARGSS 201_ NASLK 206_ EEECK 211_ EPLLF 216_ HSGDH 221_ YPLSD 226_ GDWSP 231_ LETTY 236_ PQTAC 241_ PKSDS 246_ ELEVK 251_ PAESL 256_ LRSES 261_ HMEWT 266_ WGGFP 271_ ESTKV 276_ SKRER 281_ SDHHP 286_ RTATI 291_ TPSEN 296_ THFRV 301_ IPSED 306_ NLISE 311_ VEKDA 316_ SMEDT 321_ VCTIV 326_ KPKPR 331_ ALGTQ 336_ MSDPT 341_ SVAEL 346_ LEPPL 351_ ESTQI 356_ SSMLD 361_ ADHLP 366_ NAALA 371_ EAPSE 376_ SKPAA 381_ KVDSP 386_ SKKKG 391_ VHKRS 396_ QHQGP 401_ DDIYL 406_ DDLKG 411_ LEPEV 416_ AALYF 421_ PKSES 426_ EPGSR 431_ QWPES 436_ DTLSG 441_ SQSPQ 446_ SVGSA 451_ AADSG 456_ TECLS 461_ DSAMD 466_ LPDVT 471_ LSLCG 476_ GLSEN 481_ GEISK 486_ EKFME 491_ HIITY 496_ HEFAE 501_ NPGLI 506_ DNPNL 511_ VIRIY 516_ NRYYN 521_ WALAA 526_ PMILS 531_ LQVFQ 536_ KSLPK 541_ ATVES 546_ WVKDK 551_ MPKKS 556_ GRWWF 561_ WRKRE 566_ SMTKQ 571_ LPESK 576_ EGKSE 581_ APPAS 586_ DLPSS 591_ SKEPA 596_ GARPA 601_ ENDSS 606_ SDEGS 611_ QELEE 616_ SITVD 621_ PIPTE 626_ PLSHG 631_ STTSY 636_ KKSLR 641_ LSSDQ 646_ IAKLK 651_ LHDGP 656_ NDVVF 661_ SITTQ 666_ YQGTC 671_ RCAGT 676_ IYLWN 681_ WNDKI 686_ IISDI 691_ DGTIT 696_ KSDAL 701_ GQILP 706_ QLGKD 711_ WTHQG 716_ IAKLY 721_ HSINE 726_ NGYKF 731_ LYCSA 736_ RAIGM 741_ ADMTR 746_ GYLHW 751_ VNDKG 756_ TILPR 761_ GPLML 766_ SPSSL 771_ FSAFH 776_ REVIE 781_ KKPEK 786_ FKIEC 791_ LNDIK 796_ NLFAP 801_ SKQPF 806_ YAAFG 811_ NRPND 816_ VYAYT 821_ QVGVP 826_ DCRIF 831_ TVNPK 836_ GELIQ 841_ ERTKG 846_ NKSSY 851_ HRLSE 856_ LVEHV 861_ FPLLS 866_ KEQNS 871_ AFPCP 876_ EFSSF 881_ CYWRD 886_ PIPEV 891_DLDDL
1: Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism