Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7)
1_MSLQS 6_ AQYLR 11_ QAEVL 16_ KADMT 21_ DSKLG 26_ PAEVW 31_ TSRQA 36_ LQDLY 41_ QKMLV 46_ TDLEY 51_ ALDKK 56_ VEQDL 61_ WNHAF 66_ KNQIT 71_ TLQGQ 76_ AKNRA 81_ NPNRS 86_ EVQAN 91_ LSLFL 96_ EAASG 101_ FYTQL 106_ LQELC 111_ TVFNV 116_ DLPCR 121_ VKSSQ 126_ LGIIS 131_ NKQTH 136_ TSAIV 141_ KPQSS 146_ SCSYI 151_ CQHCL 156_ VHLGD 161_ IARYR 166_ NQTSQ 171_ AESYY 176_ RHAAQ 181_ LVPSN 186_ GQPYN 191_ QLAIL 196_ ASSKG 201_ DHLTT 206_ IFYYC 211_ RSIAV 216_ KFPFP 221_ AASTN 226_ LQKAL 231_ SKALE 236_ SRDEV 241_ KTKWG 246_ VSDFI 251_ KAFIK 256_ FHGHV 261_ YLSKS 266_ LEKLS 271_ PLREK 276_ LEEQF 281_ KRLLF 286_ QKAFN 291_ SQQLV 296_ HVTVI 301_ NLFQL 306_ HHLRD 311_ FSNET 316_ EQHTY 321_ SQDEQ 326_ LCWTQ 331_ LLALF 336_ MSFLG 341_ ILCKC 346_ PLQNE 351_ SQEES 356_ YNAYP 361_ LPAVK 366_ VSMDW 371_ LRLRP 376_ RVFQE 381_ AVVDE 386_ RQYIW 391_ PWLIS 396_ LLNSF 401_ HPHEE 406_ DLSSI 411_ SATPL 416_ PEEFE 421_ LQGFL 426_ ALRPS 431_ FRNLD 436_ FSKGH 441_ QGITG 446_ DKEGQ 451_ QRRIR 456_ QQRLI 461_ SIGKW 466_ IADNQ 471_ PRLIQ 476_ CENEV 481_ GKLLF 486_ ITEIP 491_ ELILE 496_ DPSEA 501_ KENLI 506_ LQETS 511_ VIESL 516_ AADGS 521_ PGLKS 526_ VLSTS 531_ RNLSN 536_ NCDTG 541_ EKPVV 546_ TFKEN 551_ IKTRE 556_ VNRDQ 561_ GRSFP 566_ PKEVR 571_ RDYSK 576_ GITVT 581_ KNDGK 586_ KDNNK 591_ RKTET 596_ KKCTL 601_ EKLQE 606_ TGKQN 611_ VAVQV 616_ KSQTE 621_ LRKTP 626_ VSEAR 631_ KTPVT 636_ QTPTQ 641_ ASNSQ 646_ FIPIH 651_ HPGAF 656_ PPLPS 661_ RPGFP 666_ PPTYV 671_ IPPPV 676_ AFSMG 681_ SGYTF 686_ PAGVS 691_ VPGTF 696_ LQPTA 701_ HSPAG 706_ NQVQA 711_ GKQSH 716_ IPYSQ 721_ QRPSG 726_ PGPMN 731_ QGPQQ 736_ SQPPS 741_ QQPLT 746_ SLPAQ 751_ PTAQS 756_ TSQLQ 761_ VQALT 766_ QQQQS 771_ PTKAV 776_ PALGK 781_ SPPHH 786_ SGFQQ 791_ YQQAD 796_ ASKQL 801_ WNPPQ 806_ VQGPL 811_ GKIMP 816_ VKQPY 821_ YLQTQ 826_ DPIKL 831_ FEPSL 836_ QPPVM 841_ QQQPL 846_ EKKMK 851_ PFPME 856_ PYNHN 861_ PSEVK 866_ VPEFY 871_ WDSSY 876_ SMADN 881_ RSVMA 886_ QQANI 891_ DRRGK 896_ RSPGV 901_ FRPEQ 906_ DPVPR 911_ MPFEK 916_ SLLEK 921_ PSELM 926_ SHSSS 931_ FLSLT 936_ GFSLN 941_ QERYP 946_ NNSMF 951_ NEVYG 956_ KNLTS 961_ SSKAE 966_ LSPSM 971_ APQET 976_ SLYSL 981_ FEGTP 986_ WSPSL 991_ PASSD 996_ HSTPA 1001_ SQSPH 1006_ SSNPS 1011_ SLPSS 1016_ PPTHN 1021_ HNSVP 1026_ FSNFG 1031_ PIGTP 1036_ DNRDR 1041_ RTADR 1046_ WKTDK 1051_ PAMGG 1056_ FGIDY 1061_ LSATS 1066_ SSESS 1071_ WHQAS 1076_ TPSGT 1081_ WTGHG 1086_ PSMED 1091_ SSAVL 1096_ MESLK 1101_ SIWSS 1106_ SMMHP 1111_ GPSAL 1116_ EQLLM 1121_ QQKQK 1126_ QQRGQ 1131_GTMNP
1: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation