Nicastrin
1_MATAG 6_ GGSGA 11_ DPGSR 16_ GLLRL 21_ LSFCV 26_ LLAGL 31_ CRGNS 36_ VERKI 41_ YIPLN 46_ KTAPC 51_ VRLLN 56_ ATHQI 61_ GCQSS 66_ ISGDT 71_ GVIHV 76_ VEKEE 81_ DLQWV 86_ LTDGP 91_ NPPYM 96_ VLLES 101_ KHFTR 106_ DLMEK 111_ LKGRT 116_ SRIAG 121_ LAVSL 126_ TKPSP 131_ ASGFS 136_ PSVQC 141_ PNDGF 146_ GVYSN 151_ SYGPE 156_ FAHCR 161_ EIQWN 166_ SLGNG 171_ LAYED 176_ FSFPI 181_ FLLED 186_ ENETK 191_ VIKQC 196_ YQDHN 201_ LSQNG 206_ SAPTF 211_ PLCAM 216_ QLFSH 221_ MHAVI 226_ STATC 231_ MRRSS 236_ IQSTF 241_ SINPE 246_ IVCDP 251_ LSDYN 256_ VWSML 261_ KPINT 266_ TGTLK 271_ PDDRV 276_ VVAAT 281_ RLDSR 286_ SFFWN 291_ VAPGA 296_ ESAVA 301_ SFVTQ 306_ LAAAE 311_ ALQKA 316_ PDVTT 321_ LPRNV 326_ MFVFF 331_ QGETF 336_ DYIGS 341_ SRMVY 346_ DMEKG 351_ KFPVQ 356_ LENVD 361_ SFVEL 366_ GQVAL 371_ RTSLE 376_ LWMHT 381_ DPVSQ 386_ KNESV 391_ RNQVE 396_ DLLAT 401_ LEKSG 406_ AGVPA 411_ VILRR 416_ PNQSQ 421_ PLPPS 426_ SLQRF 431_ LRARN 436_ ISGVV 441_ LADHS 446_ GAFHN 451_ KYYQS 456_ IYDTA 461_ ENINV 466_ SYPEW 471_ LSPEE 476_ DLNFV 481_ TDTAK 486_ ALADV 491_ ATVLG 496_ RALYE 501_ LAGGT 506_ NFSDT 511_ VQADP 516_ QTVTR 521_ LLYGF 526_ LIKAN 531_ NSWFQ 536_ SILRQ 541_ DLRSY 546_ LGDGP 551_ LQHYI 556_ AVSSP 561_ TNTTY 566_ VVQYA 571_ LANLT 576_ GTVVN 581_ LTREQ 586_ CQDPS 591_ KVPSE 596_ NKDLY 601_ EYSWV 606_ QGPLH 611_ SNETD 616_ RLPRC 621_ VRSTA 626_ RLARA 631_ LSPAF 636_ ELSQW 641_ SSTEY 646_ STWTE 651_ SRWKD 656_ IRARI 661_ FLIAS 666_ KELEL 671_ ITLTV 676_ GFGIL 681_ IFSLI 686_ VTYCI 691_ NAKAD 696_ VLFIA 701_PREPG
1: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels