Gene name: TM9SF4

Uniprot entry:

Q92544

Protein names:

Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)

Protein sequence:

1_MATAM 6_ DWLPW 11_ SLLLF 16_ SLMCE 21_ TSAFY 26_ VPGVA 31_ PINFH 36_ QNDPV 41_ EIKAV 46_ KLTSS 51_ RTQLP 56_ YEYYS 61_ LPFCQ 66_ PSKIT 71_ YKAEN 76_ LGEVL 81_ RGDRI 86_ VNTPF 91_ QVLMN 96_ SEKKC 101_ EVLCS 106_ QSNKP 111_ VTLTV 116_ EQSRL 121_ VAERI 126_ TEDYY 131_ VHLIA 136_ DNLPV 141_ ATRLE 146_ LYSNR 151_ DSDDK 156_ KKEKD 161_ VQFEH 166_ GYRLG 171_ FTDVN 176_ KIYLH 181_ NHLSF 186_ ILYYH 191_ REDME 196_ EDQEH 201_ TYRVV 206_ RFEVI 211_ PQSIR 216_ LEDLK 221_ ADEKS 226_ SCTLP 231_ EGTNS 236_ SPQEI 241_ DPTKE 246_ NQLYF 251_ TYSVH 256_ WEESD 261_ IKWAS 266_ RWDTY 271_ LTMSD 276_ VQIHW 281_ FSIIN 286_ SVVVV 291_ FFLSG 296_ ILSMI 301_ IIRTL 306_ RKDIA 311_ NYNKE 316_ DDIED 321_ TMEES 326_ GWKLV 331_ HGDVF 336_ RPPQY 341_ PMILS 346_ SLLGS 351_ GIQLF 356_ CMILI 361_ VIFVA 366_ MLGML 371_ SPSSR 376_ GALMT 381_ TACFL 386_ FMFMG 391_ VFGGF 396_ SAGRL 401_ YRTLK 406_ GHRWK 411_ KGAFC 416_ TATLY 421_ PGVVF 426_ GICFV 431_ LNCFI 436_ WGKHS 441_ SGAVP 446_ FPTMV 451_ ALLCM 456_ WFGIS 461_ LPLVY 466_ LGYYF 471_ GFRKQ 476_ PYDNP 481_ VRTNQ 486_ IPRQI 491_ PEQRW 496_ YMNRF 501_ VGILM 506_ AGILP 511_ FGAMF 516_ IELFF 521_ IFSAI 526_ WENQF 531_ YYLFG 536_ FLFLV 541_ FIILV 546_ VSCSQ 551_ ISIVM 556_ VYFQL 561_ CAEDY 566_ RWWWR 571_ NFLVS 576_ GGSAF 581_ YVLVY 586_ AIFYF 591_ VNKLD 596_ IVEFI 601_ PSLLY 606_ FGYTA 611_ LMVLS 616_ FWLLT 621_ GTIGF 626_ YAAYM 631_ FVRKI 636_YAAVK

Protein annotations

Protein functions:

1: Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578)