RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog)
1_MIEVV 6_ AELSR 11_ GPVFL 16_ AGEAL 21_ ECVVT 26_ VTNPL 31_ PPTAT 36_ SASSE 41_ ALAWA 46_ SAQIH 51_ CQFHA 56_ SESRV 61_ ALPPP 66_ DSSQP 71_ DVQPD 76_ SQTVF 81_ LPHRG 86_ ERGQC 91_ ILSTP 96_ PKILF 101_ CDLRL 106_ DPGES 111_ KSYSY 116_ SEVLP 121_ IEGPP 126_ SFRGQ 131_ SVKYV 136_ YKLTI 141_ GCQRV 146_ NSPIT 151_ LLRVP 156_ LRVLV 161_ LTGLQ 166_ DVRFP 171_ QDEAV 176_ APSSP 181_ FLEED 186_ EGGKK 191_ DSWLA 196_ ELAGE 201_ RLMAA 206_ TSCRS 211_ LHLYN 216_ ISDGR 221_ GKVGT 226_ FGIFK 231_ SVYRL 236_ GEDVV 241_ GTLNL 246_ GEGTV 251_ ACLQF 256_ SVSLQ 261_ TEERV 266_ QPEYQ 271_ RRRGA 276_ GGVPS 281_ VSHVT 286_ HARHQ 291_ ESCLH 296_ TTRTS 301_ FSLPI 306_ PLSST 311_ PGFCT 316_ AIVSL 321_ KWRLH 326_ FEFVT 331_ SREPG 336_ LVLLP 341_ PVEQP 346_ EPTTW 351_ TGPEQ 356_ VPVDT 361_ FSWDL 366_ PIKVL 371_ PTSPT 376_ LASYA 381_ APGPS 386_TSTIT
1: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors