Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)
1_MNKGW 6_ LELES 11_ DPGLF 16_ TLLVE 21_ DFGVK 26_ GVQVE 31_ EIYDL 36_ QSKCQ 41_ GPVYG 46_ FIFLF 51_ KWIEE 56_ RRSRR 61_ KVSTL 66_ VDDTS 71_ VIDDD 76_ IVNNM 81_ FFAHQ 86_ LIPNS 91_ CATHA 96_ LLSVL 101_ LNCSS 106_ VDLGP 111_ TLSRM 116_ KDFTK 121_ GFSPE 126_ SKGYA 131_ IGNAP 136_ ELAKA 141_ HNSHA 146_ RPEPR 151_ HLPEK 156_ QNGLS 161_ AVRTM 166_ EAFHF 171_ VSYVP 176_ ITGRL 181_ FELDG 186_ LKVYP 191_ IDHGP 196_ WGEDE 201_ EWTDK 206_ ARRVI 211_ MERIG 216_ LATAG 221_ EPYHD 226_ IRFNL 231_ MAVVP 236_ DRRIK 241_ YEARL 246_ HVLKV 251_ NRQTV 256_ LEALQ 261_ QLIRV 266_ TQPEL 271_ IQTHK 276_ SQESQ 281_ LPEES 286_ KSASN 291_ KSPLV 296_ LEANR 301_ APAAS 306_ EGNHT 311_ DGAEE 316_ AAGSC 321_ AQAPS 326_ HSPPN 331_ KPKLV 336_ VKPPG 341_ SSLNG 346_ VHPNP 351_ TPIVQ 356_ RLPAF 361_ LDNHN 366_ YAKSP 371_ MQEEE 376_ DLAAG 381_ VGRSR 386_ VPVRP 391_ PQQYS 396_ DDEDD 401_ YEDDE 406_ EDDVQ 411_ NTNSA 416_ LRYKG 421_ KGTGK 426_ PGALS 431_ GSADG 436_ QLSVL 441_ QPNTI 446_ NVLAE 451_ KLKES 456_ QKDLS 461_ IPLSI 466_ KTSSG 471_ AGSPA 476_ VAVPT 481_ HSQPS 486_ PTPSN 491_ ESTDT 496_ ASEIG 501_ SAFNS 506_ PLRSP 511_ IRSAN 516_ PTRPS 521_ SPVTS 526_ HISKV 531_ LFGED 536_ DSLLR 541_ VDCIR 546_ YNRAV 551_ RDLGP 556_ VISTG 561_ LLHLA 566_ EDGVL 571_ SPLAL 576_ TEGGK 581_ GSSPS 586_ IRPIQ 591_ GSQGS 596_ SSPVE 601_ KEVVE 606_ ATDSR 611_ EKTGM 616_ VRPGE 621_ PLSGE 626_ KYSPK 631_ ELLAL 636_ LKCVE 641_ AEIAN 646_ YEACL 651_ KEEVE 656_ KRKKF 661_ KIDDQ 666_ RRTHN 671_ YDEFI 676_ CTFIS 681_ MLAQE 686_ GMLAN 691_ LVEQN 696_ ISVRR 701_ RQGVS 706_ IGRLH 711_ KQRKP 716_ DRRKR 721_SRPYK
1: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818)