Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16)
1_MPTAA 6_ APIIS 11_ SVQKL 16_ VLYET 21_ RARYF 26_ LVGSN 31_ NAETK 36_ YRVLK 41_ IDRTE 46_ PKDLV 51_ IIDDR 56_ HVYTQ 61_ QEVRE 66_ LLGRL 71_ DLGNR 76_ TKMGQ 81_ KGSSG 86_ LFRAV 91_ SAFGV 96_ VGFVR 101_ FLEGY 106_ YIVLI 111_ TKRRK 116_ MADIG 121_ GHAIY 126_ KVEDT 131_ NMIYI 136_ PNDSV 141_ RVTHP 146_ DEARY 151_ LRIFQ 156_ NVDLS 161_ SNFYF 166_ SYSYD 171_ LSHSL 176_ QYNLT 181_ VLRMP 186_ LEMLK 191_ SEMTQ 196_ NRQES 201_ FDIFE 206_ DEGLI 211_ TQGGS 216_ GVFGI 221_ CSEPY 226_ MKYVW 231_ NGELL 236_ DIIKS 241_ TVHRD 246_ WLLYI 251_ IHGFC 256_ GQSKL 261_ LIYGR 266_ PVYVT 271_ LIARR 276_ SSKFA 281_ GTRFL 286_ KRGAN 291_ CEGDV 296_ ANEVE 301_ TEQIL 306_ CDASV 311_ MSFTA 316_ GSYSS 321_ YVQVR 326_ GSVPL 331_ YWSQD 336_ ISTMM 341_ PKPPI 346_ TLDQA 351_ DPFAH 356_ VAALH 361_ FDQMF 366_ QRFGS 371_ PIIIL 376_ NLVKE 381_ REKRK 386_ HERIL 391_ SEELV 396_ AAVTY 401_ LNQFL 406_ PPEHT 411_ IVYIP 416_ WDMAK 421_ YTKSK 426_ LCNVL 431_ DRLNV 436_ IAESV 441_ VKKTG 446_ FFVNR 451_ PDSYC 456_ SILRP 461_ DEKWN 466_ ELGGC 471_ VIPTG 476_ RLQTG 481_ ILRTN 486_ CVDCL 491_ DRTNT 496_ AQFMV 501_ GKCAL 506_ AYQLY 511_ SLGLI 516_ DKPNL 521_ QFDTD 526_ AVRLF 531_ EELYE 536_ DHGDT 541_ LSLQY 546_ GGSQL 551_ VHRVK 556_ TYRKI 561_ APWTQ 566_ HSKDI 571_ MQTLS 576_ RYYSN 581_ AFSDA 586_ DRQDS 591_ INLFL 596_ GVFHP 601_ TEGKP 606_ HLWEL 611_ PTDFY 616_ LHHKN 621_ TMRLL 626_ PTRRS 631_ YTYWW 636_ TPEVI 641_ KHLPL 646_ PYDEV 651_ ICAVN 656_ LKKLI 661_ VKKFH 666_ KYEEE 671_ IDIHN 676_ EFFRP 681_ YELSS 686_ FDDTF 691_ CLAMT 696_ SSARD 701_ FMPKT 706_ VGIDP 711_ SPFTV 716_ RKPDE 721_ TGKSV 726_ LGNKS 731_ NREEA 736_ VLQRK 741_ TAASA 746_ PPPPS 751_ EEAVS 756_ SSSED 761_ DSGTD 766_ REEEG 771_ SVSQR 776_ STPVK 781_ MTDAG 786_ DSAKV 791_ TENVV 796_ QPMKE 801_ LYGIN 806_ LSDGL 811_ SEEDF 816_ SIYSR 821_ FVQLG 826_ QSQHK 831_ QDKNS 836_ QQPCS 841_ RCSDG 846_ VIKLT 851_ PISAF 856_ SQDNI 861_ YEVQP 866_ PRVDR 871_ KSTEI 876_ FQAHI 881_ QASQG 886_ IMQPL 891_ GKEDS 896_ SMYRE 901_YIRNR
1: Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:17556371, PubMed:33098764). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate (PubMed:33098764). Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production (PubMed:33098764). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro (PubMed:17556371)