Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)
1_MARRG 6_ WRRAP 11_ LRRGV 16_ GSSPR 21_ ARRLM 26_ RPLWL 31_ LLAVG 36_ VFDWA 41_ GASDG 46_ GGGEA 51_ RAMDE 56_ EIVSE 61_ KQAEE 66_ SHRQD 71_ SANLL 76_ IFILL 81_ LTLTI 86_ LTIWL 91_ FKHRR 96_ ARFLH 101_ ETGLA 106_ MIYGL 111_ LVGLV 116_ LRYGI 121_ HVPSD 126_ VNNVT 131_ LSCEV 136_ QSSPT 141_ TLLVT 146_ FDPEV 151_ FFNIL 156_ LPPII 161_ FYAGY 166_ SLKRR 171_ HFFRN 176_ LGSIL 181_ AYAFL 186_ GTAIS 191_ CFVIG 196_ SIMYG 201_ CVTLM 206_ KVTGQ 211_ LAGDF 216_ YFTDC 221_ LLFGA 226_ IVSAT 231_ DPVTV 236_ LAIFH 241_ ELQVD 246_ VELYA 251_ LLFGE 256_ SVLND 261_ AVAIV 266_ LSSSI 271_ VAYQP 276_ AGDNS 281_ HTFDV 286_ TAMFK 291_ SIGIF 296_ LGIFS 301_ GSFAM 306_ GAATG 311_ VVTAL 316_ VTKFT 321_ KLREF 326_ QLLET 331_ GLFFL 336_ MSWST 341_ FLLAE 346_ AWGFT 351_ GVVAV 356_ LFCGI 361_ TQAHY 366_ TYNNL 371_ STESQ 376_ HRTKQ 381_ LFELL 386_ NFLAE 391_ NFIFS 396_ YMGLT 401_ LFTFQ 406_ NHVFN 411_ PTFVV 416_ GAFVA 421_ IFLGR 426_ AANIY 431_ PLSLL 436_ LNLGR 441_ RSKIG 446_ SNFQH 451_ MMMFA 456_ GLRGA 461_ MAFAL 466_ AIRDT 471_ ATYAR 476_ QMMFS 481_ TTLLI 486_ VFFTV 491_ WVFGG 496_ GTTAM 501_ LSCLH 506_ IRVGV 511_ DSDQE 516_ HLGVP 521_ ENERR 526_ TTKAE 531_ SAWLF 536_ RMWYN 541_ FDHNY 546_ LKPLL 551_ THSGP 556_ PLTTT 561_ LPACC 566_ GPIAR 571_ CLTSP 576_ QAYEN 581_ QEQLK 586_ DDDSD 591_ LILND 596_ GDISL 601_ TYGDS 606_ TVNTE 611_ PATSS 616_ APRRF 621_ MGNSS 626_ EDALD 631_ RELAF 636_ GDHEL 641_ VIRGT 646_ RLVLP 651_ MDDSE 656_ PPLNL 661_LDNTR
1: Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity)