C-C motif chemokine 17 (CC chemokine TARC) (Small-inducible cytokine A17) (Thymus and activation-regulated chemokine)
1_MAPLK 6_ MLALV 11_ TLLLG 16_ ASLQH 21_ IHAAR 26_ GTNVG 31_ RECCL 36_ EYFKG 41_ AIPLR 46_ KLKTW 51_ YQTSE 56_ DCSRD 61_ AIVFV 66_ TVQGR 71_ AICSD 76_ PNNKR 81_ VKNAV 86_KYLQS
1: Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (PubMed:10540332, PubMed:9169480). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity)