Mastermind-like protein 1 (Mam-1)
1_MVLPT 6_ CPMAE 11_ FALPR 16_ HSAVM 21_ ERLRR 26_ RIELC 31_ RRHHS 36_ TCEAR 41_ YEAVS 46_ PERLE 51_ LERQH 56_ TFALH 61_ QRCIQ 66_ AKAKR 71_ AGKHR 76_ QPPAA 81_ TAPAP 86_ AAPAP 91_ RLDAA 96_ DGPEH 101_ GRPAT 106_ HLHDT 111_ VKRNL 116_ DSATS 121_ PQNGD 126_ QQNGY 131_ GDLFP 136_ GHKKT 141_ RREAP 146_ LGVAI 151_ SSNGL 156_ PPASP 161_ LGQSD 166_ KPSGA 171_ DALQS 176_ SGKHS 181_ LGLDS 186_ LNKKR 191_ LADSS 196_ LHLNG 201_ GSNPS 206_ ESFPL 211_ SLNKE 216_ LKQEP 221_ VEDLP 226_ CMITG 231_ TVGSI 236_ SQSNL 241_ MPDLN 246_ LNEQE 251_ WKELI 256_ EELNR 261_ SVPDE 266_ DMKDL 271_ FNEDF 276_ EEKKD 281_ PESSG 286_ SATQT 291_ PLAQD 296_ INIKT 301_ EFSPA 306_ AFEQE 311_ QLGSP 316_ QVRAG 321_ SAGQT 326_ FLGPS 331_ SAPVS 336_ TDSPS 341_ LGGSQ 346_ TLFHT 351_ SGQPR 356_ ADNPS 361_ PNLMP 366_ ASAQA 371_ QNAQR 376_ ALAGV 381_ VLPSQ 386_ GPGGA 391_ SELSS 396_ AHQLQ 401_ QIAAK 406_ QKREQ 411_ MLQNP 416_ QQATP 421_ APAPG 426_ QMSTW 431_ QQTGP 436_ SHSSL 441_ DVPYP 446_ MEKPA 451_ SPSSY 456_ KQDFT 461_ NSKLL 466_ MMPSV 471_ NKSSP 476_ RPGGP 481_ YLQPS 486_ HVNLL 491_ SHQPP 496_ SNLNQ 501_ NSANN 506_ QGSVL 511_ DYGNT 516_ KPLSH 521_ YKADC 526_ GQGSP 531_ GSGQS 536_ KPALM 541_ AYLPQ 546_ QLSHI 551_ SHEQN 556_ SLFLM 561_ KPKPG 566_ NMPFR 571_ SLVPP 576_ GQEQN 581_ PSSVP 586_ VQAQA 591_ TSVGT 596_ QPPAV 601_ SVASS 606_ HNSSP 611_ YLSSQ 616_ QQAAV 621_ MKQHQ 626_ LLLDQ 631_ QKQRE 636_ QQQKH 641_ LQQQQ 646_ FLQRQ 651_ QHLLA 656_ EQEKQ 661_ QFQRH 666_ LTRPP 671_ PQYQD 676_ PTQGS 681_ FPQQV 686_ GQFTG 691_ SSAAV 696_ PGMNT 701_ LGPSN 706_ SSCPR 711_ VFPQA 716_ GNLMP 721_ MGPGH 726_ ASVSS 731_ LPTNS 736_ GQQDR 741_ GVAQF 746_ PGSQN 751_ MPQSS 756_ LYGMA 761_ SGITQ 766_ IVAQP 771_ PPQAT 776_ NGHAH 781_ IPRQT 786_ NVGQN 791_ TSVSA 796_ AYGQN 801_ SLGSS 806_ GLSQQ 811_ HNKGT 816_ LNPGL 821_ TKPPV 826_ PRVSP 831_ AMGGQ 836_ NSSWQ 841_ HQGMP 846_ NLSGQ 851_ TPGNS 856_ NVSPF 861_ TAASS 866_ FHMQQ 871_ QAHLK 876_ MSSPQ 881_ FSQAV 886_ PNRPM 891_ APMSS 896_ AAAVG 901_ SLLPP 906_ VSAQQ 911_ RTSAP 916_ APAPP 921_ PTAPQ 926_ QGLPG 931_ LSPAG 936_ PELGA 941_ FSQSP 946_ ASQMG 951_ GRAGL 956_ HCTQA 961_ YPVRT 966_ AGQEL 971_ PFAYS 976_ GQPGG 981_ SGLSS 986_ VAGHT 991_ DLIDS 996_ LLKNR 1001_ TSEEW 1006_ MSDLD 1011_DLLGS
1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions