Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)
1_MSREM 6_ QDVDL 11_ AEVKP 16_ LVEKG 21_ ETITG 26_ LLQEF 31_ DVQEQ 36_ DIETL 41_ HGSVH 46_ VTLCG 51_ TPKGN 56_ RPVIL 61_ TYHDI 66_ GMNHK 71_ TCYNP 76_ LFNYE 81_ DMQEI 86_ TQHFA 91_ VCHVD 96_ APGQQ 101_ DGAAS 106_ FPAGY 111_ MYPSM 116_ DQLAE 121_ MLPGV 126_ LQQFG 131_ LKSII 136_ GMGTG 141_ AGAYI 146_ LTRFA 151_ LNNPE 156_ MVEGL 161_ VLINV 166_ NPCAE 171_ GWMDW 176_ AASKI 181_ SGWTQ 186_ ALPDM 191_ VVSHL 196_ FGKEE 201_ MQSNV 206_ EVVHT 211_ YRQHI 216_ VNDMN 221_ PGNLH 226_ LFINA 231_ YNSRR 236_ DLEIE 241_ RPMPG 246_ THTVT 251_ LQCPA 256_ LLVVG 261_ DSSPA 266_ VDAVV 271_ ECNSK 276_ LDPTK 281_ TTLLK 286_ MADCG 291_ GLPQI 296_ SQPAK 301_ LAEAF 306_ KYFVQ 311_ GMGYM 316_ PSASM 321_ TRLMR 326_ SRTAS 331_ GSSVT 336_ SLDGT 341_ RSRSH 346_ TSEGT 351_ RSRSH 356_ TSEGT 361_ RSRSH 366_ TSEGA 371_ HLDIT 376_ PNSGA 381_ AGNSA 386_GPKSM
1: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy