Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)
1_MSVVG 6_ LDVGS 11_ QSCYI 16_ AVARA 21_ GGIET 26_ IANEF 31_ SDRCT 36_ PSVIS 41_ FGSKN 46_ RTIGV 51_ AAKNQ 56_ QITHA 61_ NNTVS 66_ NFKRF 71_ HGRAF 76_ NDPFI 81_ QKEKE 86_ NLSYD 91_ LVPLK 96_ NGGVG 101_ IKVMY 106_ MGEEH 111_ LFSVE 116_ QITAM 121_ LLTKL 126_ KETAE 131_ NSLKK 136_ PVTDC 141_ VISVP 146_ SFFTD 151_ AERRS 156_ VLDAA 161_ QIVGL 166_ NCLRL 171_ MNDMT 176_ AVALN 181_ YGIYK 186_ QDLPS 191_ LDEKP 196_ RIVVF 201_ VDMGH 206_ SAFQV 211_ SACAF 216_ NKGKL 221_ KVLGT 226_ AFDPF 231_ LGGKN 236_ FDEKL 241_ VEHFC 246_ AEFKT 251_ KYKLD 256_ AKSKI 261_ RALLR 266_ LYQEC 271_ EKLKK 276_ LMSSN 281_ STDLP 286_ LNIEC 291_ FMNDK 296_ DVSGK 301_ MNRSQ 306_ FEELC 311_ AELLQ 316_ KIEVP 321_ LYSLL 326_ EQTHL 331_ KVEDV 336_ SAVEI 341_ VGGAT 346_ RIPAV 351_ KERIA 356_ KFFGK 361_ DISTT 366_ LNADE 371_ AVARG 376_ CALQC 381_ AILSP 386_ AFKVR 391_ EFSVT 396_ DAVPF 401_ PISLI 406_ WNHDS 411_ EDTEG 416_ VHEVF 421_ SRNHA 426_ APFSK 431_ VLTFL 436_ RRGPF 441_ ELEAF 446_ YSDPQ 451_ GVPYP 456_ EAKIG 461_ RFVVQ 466_ NVSAQ 471_ KDGEK 476_ SRVKV 481_ KVRVN 486_ THGIF 491_ TISTA 496_ SMVEK 501_ VPTEE 506_ NEMSS 511_ EADME 516_ CLNQR 521_ PPENP 526_ DTDKN 531_ VQQDN 536_ SEAGT 541_ QPQVQ 546_ TDAQQ 551_ TSQSP 556_ PSPEL 561_ TSEEN 566_ KIPDA 571_ DKANE 576_ KKVDQ 581_ PPEAK 586_ KPKIK 591_ VVNVE 596_ LPIEA 601_ NLVWQ 606_ LGKDL 611_ LNMYI 616_ ETEGK 621_ MIMQD 626_ KLEKE 631_ RNDAK 636_ NAVEE 641_ YVYEF 646_ RDKLC 651_ GPYEK 656_ FICEQ 661_ DHQNF 666_ LRLLT 671_ ETEDW 676_ LYEEG 681_ EDQAK 686_ QAYVD 691_ KLEEL 696_ MKIGT 701_ PVKVR 706_ FQEAE 711_ ERPKM 716_ FEELG 721_ QRLQH 726_ YAKIA 731_ ADFRN 736_ KDEKY 741_ NHIDE 746_ SEMKK 751_ VEKSV 756_ NEVME 761_ WMNNV 766_ MNAQA 771_ KKSLD 776_ QDPVV 781_ RAQEI 786_ KTKIK 791_ ELNNT 796_ CEPVV 801_ TQPKP 806_ KIESP 811_ KLERT 816_ PNGPN 821_ IDKKE 826_ EDLED 831_ KNNFG 836_ AEPPH 841_ QNGEC 846_ YPNEK 851_NSVNM
1: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)