Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase)
1_MAITL 6_ EEAPW 11_ LGWLL 16_ VKALM 21_ RFAFM 26_ VVNNL 31_ VAIPS 36_ YICYV 41_ IILQP 46_ LRVLD 51_ SKRFW 56_ YIEGI 61_ MYKWL 66_ LGMVA 71_ SWGWY 76_ AGYTV 81_ MEWGE 86_ DIKAV 91_ SKDEA 96_ VMLVN 101_ HQATG 106_ DVCTL 111_ MMCLQ 116_ DKGLV 121_ VAQMM 126_ WLMDH 131_ IFKYT 136_ NFGIV 141_ SLVHG 146_ DFFIR 151_ QGRSY 156_ RDQQL 161_ LLLKK 166_ HLENN 171_ YRSRD 176_ RKWIV 181_ LFPEG 186_ GFLRK 191_ RRETS 196_ QAFAK 201_ KNNLP 206_ FLTNV 211_ TLPRS 216_ GATKI 221_ ILNAL 226_ VAQQK 231_ NGSPA 236_ GGDAK 241_ ELDSK 246_ SKGLQ 251_ WIIDT 256_ TIAYP 261_ KAEPI 266_ DIQTW 271_ ILGYR 276_ KPTVT 281_ HVHYR 286_ IFPIK 291_ DVPLE 296_ TDDLT 301_ TWLYQ 306_ RFVEK 311_ EDLLS 316_ HFYET 321_ GAFPP 326_ SKGHK 331_ EAVSR 336_ EMTLS 341_ NLWIF 346_ LIQSF 351_ AFLSG 356_ YMWYN 361_IIQYF
1: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity)