TBC1 domain family member 5
1_MYHSL 6_ SETRH 11_ PLQPE 16_ EQEVG 21_ IDPLS 26_ SYSNK 31_ SGGDS 36_ NKNGR 41_ RTSST 46_ LDSEG 51_ TFNSY 56_ RKEWE 61_ ELFVN 66_ NNYLA 71_ TIRQK 76_ GINGQ 81_ LRSSR 86_ FRSIC 91_ WKLFL 96_ CVLPQ 101_ DKSQW 106_ ISRIE 111_ ELRAW 116_ YSNIK 121_ EIHIT 126_ NPRKV 131_ VGQQD 136_ LMINN 141_ PLSQD 146_ EGSLW 151_ NKFFQ 156_ DKELR 161_ SMIEQ 166_ DVKRT 171_ FPEMQ 176_ FFQQE 181_ NVRKI 186_ LTDVL 191_ FCYAR 196_ ENEQL 201_ LYKQG 206_ MHELL 211_ APIVF 216_ VLHCD 221_ HQAFL 226_ HASES 231_ AQPSE 236_ EMKTV 241_ LNPEY 246_ LEHDA 251_ YAVFS 256_ QLMET 261_ AEPWF 266_ STFEH 271_ DGQKG 276_ KETLM 281_ TPIPF 286_ ARPQD 291_ LGPTI 296_ AIVTK 301_ VNQIQ 306_ DHLLK 311_ KHDIE 316_ LYMHL 321_ NRLEI 326_ APQIY 331_ GLRWV 336_ RLLFG 341_ REFPL 346_ QDLLV 351_ VWDAL 356_ FADGL 361_ SLGLV 366_ DYIFV 371_ AMLLY 376_ IRDAL 381_ ISSNY 386_ QTCLG 391_ LLMHY 396_ PFIGD 401_ VHSLI 406_ LKALF 411_ LRDPK 416_ RNPRP 421_ VTYQF 426_ HPNLD 431_ YYKAR 436_ GADLM 441_ NKSRT 446_ NAKGA 451_ PLNIN 456_ KVSNS 461_ LINFG 466_ RKLIS 471_ PAMAP 476_ GSAGG 481_ PVPGG 486_ NSSSS 491_ SSVVI 496_ PTRTS 501_ AEAPS 506_ HHLQQ 511_ QQQQQ 516_ RLMKS 521_ ESMPV 526_ QLNKG 531_ LSSKN 536_ ISSSP 541_ SVESL 546_ PGGRE 551_ FTGSP 556_ PSSAT 561_ KKDSF 566_ FSNIS 571_ RSRSH 576_ SKTMG 581_ RKESE 586_ EELEA 591_ QISFL 596_ QGQLN 601_ DLDAM 606_ CKYCA 611_ KVMDT 616_ HLVNI 621_ QDVIL 626_ QENLE 631_ KEDQI 636_ LVSLA 641_ GLKQI 646_ KDILK 651_ GSLRF 656_ NQSQL 661_ EAEEN 666_ EQITI 671_ ADNHY 676_ CSSGQ 681_ GQGRG 686_ QGQSV 691_ QMSGA 696_ IKQAS 701_ SETPG 706_ CTDRG 711_ NSDDF 716_ ILISK 721_ DDDGS 726_ SARGS 731_ FSGQA 736_ QPLRT 741_ LRSTS 746_ GKSQA 751_ PVCSP 756_ LVFSD 761_ PLMGP 766_ ASASS 771_ SNPSS 776_ SPDDD 781_ SSKDS 786_GFTIV
1: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492)