ER degradation-enhancing alpha-mannosidase-like protein 1
1_MQWRA 6_ LVLGL 11_ VLLRL 16_ GLHGV 21_ LWLVF 26_ GLGPS 31_ MGFYQ 36_ RFPLS 41_ FGFQR 46_ LRSPD 51_ GPASP 56_ TSGPV 61_ GRPGG 66_ VSGPS 71_ WLQPP 76_ GTGAA 81_ QSPRK 86_ APRRP 91_ GPGMC 96_ GPANW 101_ GYVLG 106_ GRGRG 111_ PDEYE 116_ KRYSG 121_ AFPPQ 126_ LRAQM 131_ RDLAR 136_ GMFVF 141_ GYDNY 146_ MAHAF 151_ PQDEL 156_ NPIHC 161_ RGRGP 166_ DRGDP 171_ SNLNI 176_ NDVLG 181_ NYSLT 186_ LVDAL 191_ DTLAI 196_ MGNSS 201_ EFQKA 206_ VKLVI 211_ NTVSF 216_ DKDST 221_ VQVFE 226_ ATIRV 231_ LGSLL 236_ SAHRI 241_ ITDSK 246_ QPFGD 251_ MTIKD 256_ YDNEL 261_ LYMAH 266_ DLAVR 271_ LLPAF 276_ ENTKT 281_ GIPYP 286_ RVNLK 291_ TGVPP 296_ DTNNE 301_ TCTAG 306_ AGSLL 311_ VEFGI 316_ LSRLL 321_ GDSTF 326_ EWVAR 331_ RAVKA 336_ LWNLR 341_ SNDTG 346_ LLGNV 351_ VNIQT 356_ GHWVG 361_ KQSGL 366_ GAGLD 371_ SFYEY 376_ LLKSY 381_ ILFGE 386_ KEDLE 391_ MFNAA 396_ YQSIQ 401_ NYLRR 406_ GREAC 411_ NEGEG 416_ DPPLY 421_ VNVNM 426_ FSGQL 431_ MNTWI 436_ DSLQA 441_ FFPGL 446_ QVLIG 451_ DVEDA 456_ ICLHA 461_ FYYAI 466_ WKRYG 471_ ALPER 476_ YNWQL 481_ QAPDV 486_ LFYPL 491_ RPELV 496_ ESTYL 501_ LYQAT 506_ KNPFY 511_ LHVGM 516_ DILQS 521_ LEKYT 526_ KVKCG 531_ YATLH 536_ HVIDK 541_ STEDR 546_ MESFF 551_ LSETC 556_ KYLYL 561_ LFDED 566_ NPVHK 571_ SGTRY 576_ MFTTE 581_ GHIVS 586_ VDEHL 591_ RELPW 596_ KEFFS 601_ EEGGQ 606_ DQGGK 611_ SVHRP 616_ KPHEL 621_ KVINS 626_ SSNCN 631_ RVPDE 636_ RRYSL 641_ PLKSI 646_ YMRQI 651_DQMVG
1: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2