eIF-2-alpha kinase activator GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
1_MAADT 6_ QVSET 11_ LKRFA 16_ GKVTT 21_ ASVKE 26_ RREIL 31_ SELGK 36_ CVAGK 41_ DLPEG 46_ AVKGL 51_ CKLFC 56_ LTLHR 61_ YRDAA 66_ SRRAL 71_ QAAIQ 76_ QLAEA 81_ QPEAT 86_ AKNLL 91_ HSLQS 96_ SGIGS 101_ KAGVP 106_ SKSSG 111_ SAALL 116_ ALTWT 121_ CLLVR 126_ IVFPS 131_ RAKRQ 136_ GDIWN 141_ KLVEV 146_ QCLLL 151_ LEVLG 156_ GSHKH 161_ AVDGA 166_ VKKLT 171_ KLWKE 176_ NPGLV 181_ EQYLS 186_ AILSL 191_ EPNQN 196_ YAGML 201_ GLLVQ 206_ FCTSH 211_ KEMDV 216_ VSQHK 221_ SALLD 226_ FYMKN 231_ ILMSK 236_ VKPPK 241_ YLLDS 246_ CAPLL 251_ RYLSH 256_ SEFKD 261_ LILPT 266_ IQKSL 271_ LRSPE 276_ NVIET 281_ ISSLL 286_ ASVTL 291_ DLSQY 296_ AMDIV 301_ KGLAG 306_ HLKSN 311_ SPRLM 316_ DEAVL 321_ ALRNL 326_ ARQCS 331_ DSSAM 336_ ESLTK 341_ HLFAI 346_ LGGSE 351_ GKLTV 356_ VAQKM 361_ SVLSG 366_ IGSVS 371_ HHVVS 376_ GPSSQ 381_ VLNGI 386_ VAELF 391_ IPFLQ 396_ QEVHE 401_ GTLVH 406_ AVSVL 411_ ALWCN 416_ RFTME 421_ VPKKL 426_ TEWFK 431_ KAFSL 436_ KTSTS 441_ AVRHA 446_ YLQCM 451_ LASYR 456_ GDTLL 461_ QALDL 466_ LPLLI 471_ QTVEK 476_ AASQS 481_ TQVPT 486_ ITEGV 491_ AAALL 496_ LLKLS 501_ VADSQ 506_ AEAKL 511_ SSFWQ 516_ LIVDE 521_ KKQVF 526_ TSEKF 531_ LVMAS 536_ EDALC 541_ TVLHL 546_ TERLF 551_ LDHPH 556_ RLTGN 561_ KVQQY 566_ HRALV 571_ AVLLS 576_ RTWHV 581_ RRQAQ 586_ QTVRK 591_ LLSSL 596_ GGFKL 601_ AHGLL 606_ EELKT 611_ VLSSH 616_ KVLPL 621_ EALVT 626_ DAGEV 631_ TEAGK 636_ AYVPP 641_ RVLQE 646_ ALCVI 651_ SGVPG 656_ LKGDV 661_ TDTEQ 666_ LAQEM 671_ LIISH 676_ HPSLV 681_ AVQSG 686_ LWPAL 691_ LARMK 696_ IDPEA 701_ FITRH 706_ LDQII 711_ PRMTT 716_ QSPLN 721_ QSSMN 726_ AMGSL 731_ SVLSP 736_ DRVLP 741_ QLIST 746_ ITASV 751_ QNPAL 756_ RLVTR 761_ EEFAI 766_ MQTPA 771_ GELYD 776_ KSIIQ 781_ SAQQD 786_ SIKKA 791_ NMKRE 796_ NKAYS 801_ FKEQI 806_ IELEL 811_ KEEIK 816_ KKKGI 821_ KEEVQ 826_ LTSKQ 831_ KEMLQ 836_ AQLDR 841_ EAQVR 846_ RRLQE 851_ LDGEL 856_ EAALG 861_ LLDII 866_ LAKNP 871_ SGLTQ 876_ YIPVL 881_ VDSFL 886_ PLLKS 891_ PLAAP 896_ RIKNP 901_ FLSLA 906_ ACVMP 911_ SRLKA 916_ LGTLV 921_ SHVTL 926_ RLLKP 931_ ECVLD 936_ KSWCQ 941_ EELSV 946_ AVKRA 951_ VMLLH 956_ THTIT 961_ SRVGK 966_ GEPGA 971_ APLSA 976_ PAFSL 981_ VFPFL 986_ KMVLT 991_ EMPHH 996_ SEEEE 1001_ EWMAQ 1006_ ILQIL 1011_ TVQAQ 1016_ LRASP 1021_ NTPPG 1026_ RVDEN 1031_ GPELL 1036_ PRVAM 1041_ LRLLT 1046_ WVIGT 1051_ GSPRL 1056_ QVLAS 1061_ DTLTT 1066_ LCASS 1071_ SGDDG 1076_ CAFAE 1081_ QEEVD 1086_ VLLCA 1091_ LQSPC 1096_ ASVRE 1101_ TVLRG 1106_ LMELH 1111_ MVLPA 1116_ PDTDE 1121_ KNGLN 1126_ LLRRL 1131_ WVVKF 1136_ DKEEE 1141_ IRKLA 1146_ ERLWS 1151_ MMGLD 1156_ LQPDL 1161_ CSLLI 1166_ DDVIY 1171_ HEAAV 1176_ RQAGA 1181_ EALSQ 1186_ AVARY 1191_ QRQAA 1196_ EVMGR 1201_ LMEIY 1206_ QEKLY 1211_ RPPPV 1216_ LDALG 1221_ RVISE 1226_ SPPDQ 1231_ WEARC 1236_ GLALA 1241_ LNKLS 1246_ QYLDS 1251_ SQVKP 1256_ LFQFF 1261_ VPDAL 1266_ NDRHP 1271_ DVRKC 1276_ MLDAA 1281_ LATLN 1286_ THGKE 1291_ NVNSL 1296_ LPVFE 1301_ EFLKN 1306_ APNDA 1311_ SYDAV 1316_ RQSVV 1321_ VLMGS 1326_ LAKHL 1331_ DKSDP 1336_ KVKPI 1341_ VAKLI 1346_ AALST 1351_ PSQQV 1356_ QESVA 1361_ SCLPP 1366_ LVPAI 1371_ KEDAG 1376_ GMIQR 1381_ LMQQL 1386_ LESDK 1391_ YAERK 1396_ GAAYG 1401_ LAGLV 1406_ KGLGI 1411_ LSLKQ 1416_ QEMMA 1421_ ALTDA 1426_ IQDKK 1431_ NFRRR 1436_ EGALF 1441_ AFEML 1446_ CTMLG 1451_ KLFEP 1456_ YVVHV 1461_ LPHLL 1466_ LCFGD 1471_ GNQYV 1476_ REAAD 1481_ DCAKA 1486_ VMSNL 1491_ SAHGV 1496_ KLVLP 1501_ SLLAA 1506_ LEEES 1511_ WRTKA 1516_ GSVEL 1521_ LGAMA 1526_ YCAPK 1531_ QLSSC 1536_ LPNIV 1541_ PKLTE 1546_ VLTDS 1551_ HVKVQ 1556_ KAGQQ 1561_ ALRQI 1566_ GSVIR 1571_ NPEIL 1576_ AIAPV 1581_ LLDAL 1586_ TDPSR 1591_ KTQKC 1596_ LQTLL 1601_ DTKFV 1606_ HFIDA 1611_ PSLAL 1616_ IMPIV 1621_ QRAFQ 1626_ DRSTD 1631_ TRKMA 1636_ AQIIG 1641_ NMYSL 1646_ TDQKD 1651_ LAPYL 1656_ PSVTP 1661_ GLKAS 1666_ LLDPV 1671_ PEVRT 1676_ VSAKA 1681_ LGAMV 1686_ KGMGE 1691_ SCFED 1696_ LLPWL 1701_ METLT 1706_ YEQSS 1711_ VDRSG 1716_ AAQGL 1721_ AEVMA 1726_ GLGVE 1731_ KLEKL 1736_ MPEIV 1741_ ATASK 1746_ VDIAP 1751_ HVRDG 1756_ YIMMF 1761_ NYLPI 1766_ TFGDK 1771_ FTPYV 1776_ GPIIP 1781_ CILKA 1786_ LADEN 1791_ EFVRD 1796_ TALRA 1801_ GQRVI 1806_ SMYAE 1811_ TAIAL 1816_ LLPQL 1821_ EQGLF 1826_ DDLWR 1831_ IRFSS 1836_ VQLLG 1841_ DLLFH 1846_ ISGVT 1851_ GKMTT 1856_ ETASE 1861_ DDNFG 1866_ TAQSN 1871_ KAIIT 1876_ ALGVE 1881_ RRNRV 1886_ LAGLY 1891_ MGRSD 1896_ TQLVV 1901_ RQASL 1906_ HVWKI 1911_ VVSNT 1916_ PRTLR 1921_ EILPT 1926_ LFGLL 1931_ LGFLA 1936_ STCAD 1941_ KRTIA 1946_ ARTLG 1951_ DLVRK 1956_ LGEKI 1961_ LPEII 1966_ PILEE 1971_ GLRSQ 1976_ KSDER 1981_ QGVCI 1986_ GLSEI 1991_ MKSTS 1996_ RDAVL 2001_ YFSES 2006_ LVPTA 2011_ RKALC 2016_ DPLEE 2021_ VREAA 2026_ AKTFE 2031_ QLHST 2036_ IGHQA 2041_ LEDIL 2046_ PFLLK 2051_ QLDDE 2056_ EVSEF 2061_ ALDGL 2066_ KQVMA 2071_ IKSRV 2076_ VLPYL 2081_ VPKLT 2086_ TPPVN 2091_ TRVLA 2096_ FLSSV 2101_ AGDAL 2106_ TRHLG 2111_ VILPA 2116_ VMLAL 2121_ KEKLG 2126_ TPDEQ 2131_ LEMAN 2136_ CQAVI 2141_ LSVED 2146_ DTGHR 2151_ IIIED 2156_ LLEAT 2161_ RSPEV 2166_ GMRQA 2171_ AAIIL 2176_ NIYCS 2181_ RSKAD 2186_ YTSHL 2191_ RSLVS 2196_ GLIRL 2201_ FNDSS 2206_ PVVLE 2211_ ESWDA 2216_ LNAIT 2221_ KKLDA 2226_ GNQLA 2231_ LIEEL 2236_ HKEIR 2241_ LIGNE 2246_ SKGEH 2251_ VPGFC 2256_ LPKKG 2261_ VTSIL 2266_ PVLRE 2271_ GVLTG 2276_ SPEQK 2281_ EEAAK 2286_ ALGLV 2291_ IRLTS 2296_ ADALR 2301_ PSVVS 2306_ ITGPL 2311_ IRILG 2316_ DRFSW 2321_ NVKAA 2326_ LLETL 2331_ SLLLA 2336_ KVGIA 2341_ LKPFL 2346_ PQLQT 2351_ TFTKA 2356_ LQDSN 2361_ RGVRL 2366_ KAADA 2371_ LGKLI 2376_ SIHIK 2381_ VDPLF 2386_ TELLN 2391_ GIRAM 2396_ EDPGV 2401_ RDTML 2406_ QALRF 2411_ VIQGA 2416_ GAKVD 2421_ AVIRK 2426_ NIVSL 2431_ LLSML 2436_ GHDED 2441_ NTRIS 2446_ SAGCL 2451_ GELCA 2456_ FLTEE 2461_ ELSAV 2466_ LQQCL 2471_ LADVS 2476_ GIDWM 2481_ VRHGR 2486_ SLALS 2491_ VAVNV 2496_ APGRL 2501_ CAGRY 2506_ SSDVQ 2511_ EMILS 2516_ SATAD 2521_ RIPIA 2526_ VSGVR 2531_ GMGFL 2536_ MRHHI 2541_ ETGGG 2546_ QLPAK 2551_ LSSLF 2556_ VKCLQ 2561_ NPSSD 2566_ IRLVA 2571_ EKMIW 2576_ WANKD 2581_ PLPPL 2586_ DPQAI 2591_ KPILK 2596_ ALLDN 2601_ TKDKN 2606_ TVVRA 2611_ YSDQA 2616_ IVNLL 2621_ KMRQG 2626_ EEVFQ 2631_ SLSKI 2636_ LDVAS 2641_ LEVLN 2646_ EVNRR 2651_ SLKKL 2656_ ASQAD 2661_ STEQV 2666_DDTIL
1: Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity)