Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)
1_MRPEG 6_ AGMEL 11_ GGGEE 16_ RLPEE 21_ SRREH 26_ WQLLG 31_ NLKTT 36_ VEGLV 41_ STNSP 46_ NVWSK 51_ YGGLE 56_ RLCRD 61_ MQSIL 66_ YHGLI 71_ RDQAC 76_ RRQTD 81_ YWQFV 86_ KDIRW 91_ LSPHS 96_ ALHVE 101_ KFISV 106_ HENDQ 111_ SSADG 116_ ASERA 121_ VAELW 126_ LQHSL 131_ QYHCL 136_ SAQLR 141_ PLLGD 146_ RQYIR 151_ KFYTD 156_ AAFLL 161_ SDAHV 166_ TAMLQ 171_ CLEAV 176_ EQNNP 181_ RLLAQ 186_ IDASM 191_ FARKH 196_ ESPLL 201_ VTKSQ 206_ SLTAL 211_ PSSTY 216_ TPPNS 221_ YAQHS 226_ YFGSF 231_ SSLHQ 236_ SVPNN 241_ GSERR 246_ STSFP 251_ LSGPP 256_ RKPQE 261_ SRGHV 266_ SPAED 271_ QTIQA 276_ PPVSV 281_ SALAR 286_ DSPLT 291_ PNEMS 296_ SSTLT 301_ SPIEA 306_ SWVSS 311_ QNDSP 316_ GDASE 321_ GPEYL 326_ AIGNL 331_ DPRGR 336_ TASCQ 341_ SHSSN 346_ AESSS 351_ SNLFS 356_ SSSSQ 361_ KPDSA 366_ ASSLG 371_ DQEGG 376_ GESQL 381_ SSVLR 386_ RSSFS 391_ EGQTL 396_ TVTSG 401_ AKKSH 406_ IRSHS 411_ DTSIA 416_ SRGAP 421_ ESCND 426_ KAKLR 431_ GPLPY 436_ SGQSS 441_ EVSTP 446_ SSLYM 451_ EYEGG 456_ RYLCS 461_ GEGMF 466_ RRPSE 471_ GQSLI 476_ SYLSE 481_ QDFGS 486_ CADLE 491_ KENAH 496_ FSISE 501_ SLIAA 506_ IELMK 511_ CNMMS 516_ QCLEE 521_ EEVEE 526_ EDSDR 531_ EIQEL 536_ KQKIR 541_ LRRQQ 546_ IRTKN 551_ LLPMY 556_ QEAEH 561_ GSFRV 566_ TSSSS 571_ QFSSR 576_ DSAQL 581_ SDSGS 586_ ADEVD 591_ EFEIQ 596_ DADIR 601_ RNTAS 606_ SSKSF 611_ VSSQS 616_ FSHCF 621_ LHSTS 626_ AEAVA 631_ MGLLK 636_ QFEGM 641_ QLPAA 646_ SELEW 651_ LVPEH 656_ DAPQK 661_ LLPIP 666_ DSLPI 671_ SPDDG 676_ QHADI 681_ YKLRI 686_ RVRGN 691_ LEWAP 696_ PRPQI 701_ IFNVH 706_ PAPTR 711_ KIAVA 716_ KQNYR 721_ CAGCG 726_ IRTDP 731_ DYIKR 736_ LRYCE 741_ YLGKY 746_ FCQCC 751_ HENAQ 756_ MAIPS 761_ RVLRK 766_ WDFSK 771_ YYVSN 776_ FSKDL 781_ LIKIW 786_ NDPLF 791_ NVQDI 796_ NSALY 801_ RKVKL 806_ LNQVR 811_ LLRVQ 816_ LCHMK 821_ NMFKT 826_ CRLAK 831_ ELLDS 836_ FDTVP 841_ GHLTE 846_ DLHLY 851_ SLNDL 856_ TATRK 861_ GELGP 866_ RLAEL 871_ TRAGA 876_ THVER 881_ CMLCQ 886_ AKGFI 891_ CEFCQ 896_ NEDDI 901_ IFPFE 906_ LHKCR 911_ TCEEC 916_ KACYH 921_ KACFK 926_ SGSCP 931_ RCERL 936_ QARRE 941_ ALARQ 946_ SLESY 951_ LSDYE 956_ EEPAE 961_ ALALE 966_AAVLE
1: Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745)
2: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967)