Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)
1_MAAVE 6_ LEWIP 11_ ETLYN 16_ TAISA 21_ VVDNY 26_ IRSRR 31_ DIRSL 36_ PENIQ 41_ FDVYY 46_ KLYQQ 51_ GRLCQ 56_ LGSEF 61_ CELEV 66_ FAKVL 71_ RALDK 76_ RHLLH 81_ HCFQA 86_ LMDHG 91_ VKVAS 96_ VLAYS 101_ FSRRC 106_ SYIAE 111_ SDAAV 116_ KEKAI 121_ QVGFV 126_ LGGFL 131_ SDAGW 136_ YSDAE 141_ KVFLS 146_ CLQLC 151_ TLHDE 156_ MLHWF 161_ RAVEC 166_ CVRLL 171_ HVRNG 176_ NCKYH 181_ LGEET 186_ FKLAQ 191_ TYMDK 196_ LSKHG 201_ QQANK 206_ AALYG 211_ ELCAL 216_ LFAKS 221_ HYDEA 226_ YKWCI 231_ EAMKE 236_ ITAGL 241_ PVKVV 246_ VDVLR 251_ QASKA 256_ CVVKR 261_ EFKKA 266_ EQLIK 271_ HAVYL 276_ ARDHF 281_ GSKHP 286_ KYSDT 291_ LLDYG 296_ FYLLN 301_ VDNIC 306_ QSVAI 311_ YQAAL 316_ DIRQS 321_ VFGGK 326_ NIHVA 331_ TAHED 336_ LAYSS 341_ YVHQY 346_ SSGKF 351_ DNALF 356_ HAERA 361_ IGIIT 366_ HILPE 371_ DHLLL 376_ ASSKR 381_ VKALI 386_ LEEIA 391_ IDCHN 396_ KETEQ 401_ RLLQE 406_ AHDLH 411_ LSSLQ 416_ LAKKA 421_ FGEFN 426_ VQTAK 431_ HYGNL 436_ GRLYQ 441_ SMRKF 446_ KEAEE 451_ MHIKA 456_ IQIKE 461_ QLLGQ 466_ EDYEV 471_ ALSVG 476_ HLASL 481_ YNYDM 486_ NQYEN 491_ AEKLY 496_ LRSIA 501_ IGKKL 506_ FGEGY 511_ SGLEY 516_ DYRGL 521_ IKLYN 526_ SIGNY 531_ EKVFE 536_ YHNVL 541_ SNWNR 546_ LRDRQ 551_ YSVTD 556_ ALEDV 561_ STSPQ 566_ STEEV 571_ VQSFL 576_ISQNV
1: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960)