Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment]
1_MAKRS 6_ RGPGR 11_ RCLLA 16_ LVLFC 21_ AWGTL 26_ AVVAQ 31_ KPGAG 36_ CPSRC 41_ LCFRT 46_ TVRCM 51_ HLLLE 56_ AVPAV 61_ APQTS 66_ ILDLR 71_ FNRIR 76_ EIQPG 81_ AFRRL 86_ RNLNT 91_ LLLNN 96_ NQIKR 101_ IPSGA 106_ FEDLE 111_ NLKYL 116_ YLYKN 121_ EIQSI 126_ DRQAF 131_ KGLAS 136_ LEQLY 141_ LHFNQ 146_ IETLD 151_ PDSFQ 156_ HLPKL 161_ ERLFL 166_ HNNRI 171_ THLVP 176_ GTFNH 181_ LESMK 186_ RLRLD 191_ SNTLH 196_ CDCEI 201_ LWLAD 206_ LLKTY 211_ AESGN 216_ AQAAA 221_ ICEYP 226_ RRIQG 231_ RSVAT 236_ ITPEE 241_ LNCER 246_ PRITS 251_ EPQDA 256_ DVTSG 261_ NTVYF 266_ TCRAE 271_ GNPKP 276_ EIIWL 281_ RNNNE 286_ LSMKT 291_ DSRLN 296_ LLDDG 301_ TLMIQ 306_ NTQET 311_ DQGIY 316_ QCMAK 321_ NVAGE 326_ VKTQE 331_ VTLRY 336_ FGSPA 341_ RPTFV 346_ IQPQN 351_ TEVLV 356_ GESVT 361_ LECSA 366_ TGHPP 371_ PRISW 376_ TRGDR 381_ TPLPV 386_ DPRVN 391_ ITPSG 396_ GLYIQ 401_ NVVQG 406_ DSGEY 411_ ACSAT 416_ NNIDS 421_ VHATA 426_ FIIVQ 431_ ALPQF 436_ TVTPQ 441_ DRVVI 446_ EGQTV 451_ DFQCE 456_ AKGNP 461_ PPVIA 466_ WTKGG 471_ SQLSV 476_ DRRHL 481_ VLSSG 486_ TLRIS 491_ GVALH 496_ DQGQY 501_ ECQAV 506_ NIIGS 511_ QKVVA 516_ HLTVQ 521_ PRVTP 526_ VFASI 531_ PSDTT 536_ VEVGA 541_ NVQLP 546_ CSSQG 551_ EPEPA 556_ ITWNK 561_ DGVQV 566_ TESGK 571_ FHISP 576_ EGFLT 581_ INDVG 586_ PADAG 591_ RYECV 596_ ARNTI 601_ GSASV 606_ SMVLS 611_ VNVPD 616_ VSRNG 621_ DPFVA 626_ TSIVE 631_ AIATV 636_ DRAIN 641_ STRTH 646_ LFDSR 651_ PRSPN 656_ DLLAL 661_ FRYPR 666_ DPYTV 671_ EQARA 676_ GEIFE 681_ RTLQL 686_ IQEHV 691_ QHGLM 696_ VDLNG 701_ TSYHY 706_ NDLVS 711_ PQYLN 716_ LIANL 721_ SGCTA 726_ HRRVN 731_ NCSDM 736_ CFHQK 741_ YRTHD 746_ GTCNN 751_ LQHPM 756_ WGASL 761_ TAFER 766_ LLKSV 771_ YENGF 776_ NTPRG 781_ INPHR 786_ LYNGH 791_ ALPMP 796_ RLVST 801_ TLIGT 806_ ETVTP 811_ DEQFT 816_ HMLMQ 821_ WGQFL 826_ DHDLD 831_ STVVA 836_ LSQAR 841_ FSDGQ 846_ HCSNV 851_ CSNDP 856_ PCFSV 861_ MIPPN 866_ DSRAR 871_ SGARC 876_ MFFVR 881_ SSPVC 886_ GSGMT 891_ SLLMN 896_ SVYPR 901_ EQINQ 906_ LTSYI 911_ DASNV 916_ YGSTE 921_ HEARS 926_ IRDLA 931_ SHRGL 936_ LRQGI 941_ VQRSG 946_ KPLLP 951_ FATGP 956_ PTECM 961_ RDENE 966_ SPIPC 971_ FLAGD 976_ HRANE 981_ QLGLT 986_ SMHTL 991_ WFREH 996_ NRIAT 1001_ ELLKL 1006_ NPHWD 1011_ GDTIY 1016_ YETRK 1021_ IVGAE 1026_ IQHIT 1031_ YQHWL 1036_ PKILG 1041_ EVGMR 1046_ TLGEY 1051_ HGYDP 1056_ GINAG 1061_ IFNAF 1066_ ATAAF 1071_ RFGHT 1076_ LVNPL 1081_ LYRLD 1086_ ENFQP 1091_ IAQDH 1096_ LPLHK 1101_ AFFSP 1106_ FRIVN 1111_ EGGID 1116_ PLLRG 1121_ LFGVA 1126_ GKMRV 1131_ PSQLL 1136_ NTELT 1141_ ERLFS 1146_ MAHTV 1151_ ALDLA 1156_ AINIQ 1161_ RGRDH 1166_ GIPPY 1171_ HDYRV 1176_ YCNLS 1181_ AAHTF 1186_ EDLKN 1191_ EIKNP 1196_ EIREK 1201_ LKRLY 1206_ GSTLN 1211_ IDLFP 1216_ ALVVE 1221_ DLVPG 1226_ SRLGP 1231_ TLMCL 1236_ LSTQF 1241_ KRLRD 1246_ GDRLW 1251_ YENPG 1256_ VFSPA 1261_ QLTQI 1266_ KQTSL 1271_ ARILC 1276_ DNADN 1281_ ITRVQ 1286_ SDVFR 1291_ VAEFP 1296_ HGYGS 1301_ CDEIP 1306_ RVDLR 1311_ VWQDC 1316_ CEDCR 1321_ TRGQF 1326_ NAFSY 1331_ HFRGR 1336_ RSLEF 1341_ SYQED 1346_ KPTKK 1351_ TRPRK 1356_ IPSVG 1361_ RQGEH 1366_ LSNST 1371_ SAFST 1376_ RSDAS 1381_ GTNDF 1386_ REFVL 1391_ EMQKT 1396_ ITDLR 1401_ TQIKK 1406_ LESRL 1411_ STTEC 1416_ VDAGG 1421_ ESHAN 1426_ NTKWK 1431_ KDACT 1436_ ICECK 1441_ DGQVT 1446_ CFVEA 1451_ CPPAT 1456_ CAVPV 1461_ NIPGA 1466_ CCPVC 1471_LQKRA
1: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:18929642, PubMed:19590037, PubMed:22842973, PubMed:25708780, PubMed:25713063, PubMed:27697841, PubMed:28154175, PubMed:34679700). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (PubMed:19590037, PubMed:32543734, PubMed:34679700). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (PubMed:32543734). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (PubMed:25713063). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes (PubMed:32571911). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (PubMed:28154175). Binds laminins (PubMed:32485152). May play a role in the organization of eyeball structure and lens development during eye development (By similarity)