Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
1_MLTRK 6_ PSAAA 11_ PAAYP 16_ TGRGG 21_ DSAVR 26_ QLQAS 31_ PGLGA 36_ GATRS 41_ GVGTG 46_ PPSPI 51_ ALPPL 56_ RASNA 61_ AAAAH 66_ TIGGS 71_ KHTMN 76_ DHLHV 81_ GSHAH 86_ GQIQV 91_ QQLFE 96_ DNSNK 101_ RTVLT 106_ TQPNG 111_ LTTVG 116_ KTGLP 121_ VVPER 126_ QLDSI 131_ HRRQG 136_ SSTSL 141_ KSMEG 146_ MGKVK 151_ ATPMT 156_ PEQAM 161_ KQYMQ 166_ KLTAF 171_ EHHEI 176_ FSYPE 181_ IYFLG 186_ LNAKK 191_ RQGMT 196_ GGPNN 201_ GGYDD 206_ DQGSY 211_ VQVPH 216_ DHVAY 221_ RYEVL 226_ KVIGK 231_ GSFGQ 236_ VVKAY 241_ DHKVH 246_ QHVAL 251_ KMVRN 256_ EKRFH 261_ RQAAE 266_ EIRIL 271_ EHLRK 276_ QDKDN 281_ TMNVI 286_ HMLEN 291_ FTFRN 296_ HICMT 301_ FELLS 306_ MNLYE 311_ LIKKN 316_ KFQGF 321_ SLPLV 326_ RKFAH 331_ SILQC 336_ LDALH 341_ KNRII 346_ HCDLK 351_ PENIL 356_ LKQQG 361_ RSGIK 366_ VIDFG 371_ SSCYE 376_ HQRVY 381_ TYIQS 386_ RFYRA 391_ PEVIL 396_ GARYG 401_ MPIDM 406_ WSLGC 411_ ILAEL 416_ LTGYP 421_ LLPGE 426_ DEGDQ 431_ LACMI 436_ ELLGM 441_ PSQKL 446_ LDASK 451_ RAKNF 456_ VSSKG 461_ YPRYC 466_ TVTTL 471_ SDGSV 476_ VLNGG 481_ RSRRG 486_ KLRGP 491_ PESRE 496_ WGNAL 501_ KGCDD 506_ PLFLD 511_ FLKQC 516_ LEWDP 521_ AVRMT 526_ PGQAL 531_ RHPWL 536_ RRRLP 541_ KPPTG 546_ EKTSV 551_ KRITE 556_ STGAI 561_ TSISK 566_ LPPPS 571_ SSASK 576_ LRTNL 581_ AQMTD 586_ ANGNI 591_ QQRTV 596_LPKLV
1: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro)