Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)
1_MAAIS 6_ TSIPV 11_ ISQPQ 16_ FTAMN 21_ EPQCF 26_ YNESI 31_ AFFYN 36_ RSGKH 41_ LATEW 46_ NTVSK 51_ LVMGL 56_ GITVC 61_ IFIML 66_ ANLLV 71_ MVAIY 76_ VNRRF 81_ HFPIY 86_ YLMAN 91_ LAAAD 96_ FFAGL 101_ AYFYL 106_ MFNTG 111_ PNTRR 116_ LTVST 121_ WLLRQ 126_ GLIDT 131_ SLTAS 136_ VANLL 141_ AIAIE 146_ RHITV 151_ FRMQL 156_ HTRMS 161_ NRRVV 166_ VVIVV 171_ IWTMA 176_ IVMGA 181_ IPSVG 186_ WNCIC 191_ DIENC 196_ SNMAP 201_ LYSDS 206_ YLVFW 211_ AIFNL 216_ VTFVV 221_ MVVLY 226_ AHIFG 231_ YVRQR 236_ TMRMS 241_ RHSSG 246_ PRRNR 251_ DTMMS 256_ LLKTV 261_ VIVLG 266_ AFIIC 271_ WTPGL 276_ VLLLL 281_ DVCCP 286_ QCDVL 291_ AYEKF 296_ FLLLA 301_ EFNSA 306_ MNPII 311_ YSYRD 316_ KEMSA 321_ TFRQI 326_ LCCQR 331_ SENPT 336_ GPTEG 341_ SDRSA 346_ SSLNH 351_ TILAG 356_VHSND
1: Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity)