Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
1_MATRS 6_ SRRES 11_ RLPFL 16_ FTLVA 21_ LLPPG 26_ ALCEV 31_ WTQRL 36_ HGGSA 41_ PLPQD 46_ RGFLV 51_ VQGDP 56_ RELRL 61_ WARGD 66_ ARGAS 71_ RADEK 76_ PLRRK 81_ RSAAL 86_ QPEPI 91_ KVYGQ 96_ VSLND 101_ SHNQM 106_ VVHWA 111_ GEKSN 116_ VIVAL 121_ ARDSL 126_ ALARP 131_ KSSDV 136_ YVSYD 141_ YGKSF 146_ KKISD 151_ KLNFG 156_ LGNRS 161_ EAVIA 166_ QFYHS 171_ PADNK 176_ RYIFA 181_ DAYAQ 186_ YLWIT 191_ FDFCN 196_ TLQGF 201_ SIPFR 206_ AADLL 211_ LHSKA 216_ SNLLL 221_ GFDRS 226_ HPNKQ 231_ LWKSD 236_ DFGQT 241_ WIMIQ 246_ EHVKS 251_ FSWGI 256_ DPYDK 261_ PNTIY 266_ IERHE 271_ PSGYS 276_ TVFRS 281_ TDFFQ 286_ SRENQ 291_ EVILE 296_ EVRDF 301_ QLRDK 306_ YMFAT 311_ KVVHL 316_ LGSEQ 321_ QSSVQ 326_ LWVSF 331_ GRKPM 336_ RAAQF 341_ VTRHP 346_ INEYY 351_ IADAS 356_ EDQVF 361_ VCVSH 366_ SNNRT 371_ NLYIS 376_ EAEGL 381_ KFSLS 386_ LENVL 391_ YYSPG 396_ GAGSD 401_ TLVRY 406_ FANEP 411_ FADFH 416_ RVEGL 421_ QGVYI 426_ ATLIN 431_ GSMNE 436_ ENMRS 441_ VITFD 446_ KGGTW 451_ EFLQA 456_ PAFTG 461_ YGEKI 466_ NCELS 471_ QGCSL 476_ HLAQR 481_ LSQLL 486_ NLQLR 491_ RMPIL 496_ SKESA 501_ PGLII 506_ ATGSV 511_ GKNLA 516_ SKTNV 521_ YISSS 526_ AGARW 531_ REALP 536_ GPHYY 541_ TWGDH 546_ GGIIT 551_ AIAQG 556_ METNE 561_ LKYST 566_ NEGET 571_ WKTFI 576_ FSEKP 581_ VFVYG 586_ LLTEP 591_ GEKST 596_ VFTIF 601_ GSNKE 606_ NVHSW 611_ LILQV 616_ NATDA 621_ LGVPC 626_ TENDY 631_ KLWSP 636_ SDERG 641_ NECLL 646_ GHKTV 651_ FKRRT 656_ PHATC 661_ FNGED 666_ FDRPV 671_ VVSNC 676_ SCTRE 681_ DYECD 686_ FGFKM 691_ SEDLS 696_ LEVCV 701_ PDPEF 706_ SGKSY 711_ SPPVP 716_ CPVGS 721_ TYRRT 726_ RGYRK 731_ ISGDT 736_ CSGGD 741_ VEARL 746_ EGELV 751_ PCPLA 756_ EENEF 761_ ILYAV 766_ RKSIY 771_ RYDLA 776_ SGATE 781_ QLPLT 786_ GLRAA 791_ VALDF 796_ DYEHN 801_ CLYWS 806_ DLALD 811_ VIQRL 816_ CLNGS 821_ TGQEV 826_ IINSG 831_ LETVE 836_ ALAFE 841_ PLSQL 846_ LYWVD 851_ AGFKK 856_ IEVAN 861_ PDGDF 866_ RLTIV 871_ NSSVL 876_ DRPRA 881_ LVLVP 886_ QEGVM 891_ FWTDW 896_ GDLKP 901_ GIYRS 906_ NMDGS 911_ AAYHL 916_ VSEDV 921_ KWPNG 926_ ISVDD 931_ QWIYW 936_ TDAYL 941_ ECIER 946_ ITFSG 951_ QQRSV 956_ ILDNL 961_ PHPYA 966_ IAVFK 971_ NEIYW 976_ DDWSQ 981_ LSIFR 986_ ASKYS 991_ GSQME 996_ ILANQ 1001_ LTGLM 1006_ DMKIF 1011_ YKGKN 1016_ TGSNA 1021_ CVPRP 1026_ CSLLC 1031_ LPKAN 1036_ NSRSC 1041_ RCPED 1046_ VSSSV 1051_ LPSGD 1056_ LMCDC 1061_ PQGYQ 1066_ LKNNT 1071_ CVKQE 1076_ NTCLR 1081_ NQYRC 1086_ SNGNC 1091_ INSIW 1096_ WCDFD 1101_ NDCGD 1106_ MSDER 1111_ NCPTT 1116_ ICDLD 1121_ TQFRC 1126_ QESGT 1131_ CIPLS 1136_ YKCDL 1141_ EDDCG 1146_ DNSDE 1151_ SHCEM 1156_ HQCRS 1161_ DEYNC 1166_ SSGMC 1171_ IRSSW 1176_ VCDGD 1181_ NDCRD 1186_ WSDEA 1191_ NCTAI 1196_ YHTCE 1201_ ASNFQ 1206_ CRNGH 1211_ CIPQR 1216_ WACDG 1221_ DTDCQ 1226_ DGSDE 1231_ DPVNC 1236_ EKKCN 1241_ GFRCP 1246_ NGTCI 1251_ PSSKH 1256_ CDGLR 1261_ DCSDG 1266_ SDEQH 1271_ CEPLC 1276_ THFMD 1281_ FVCKN 1286_ RQQCL 1291_ FHSMV 1296_ CDGII 1301_ QCRDG 1306_ SDEDA 1311_ AFAGC 1316_ SQDPE 1321_ FHKVC 1326_ DEFGF 1331_ QCQNG 1336_ VCISL 1341_ IWKCD 1346_ GMDDC 1351_ GDYSD 1356_ EANCE 1361_ NPTEA 1366_ PNCSR 1371_ YFQFR 1376_ CENGH 1381_ CIPNR 1386_ WKCDR 1391_ ENDCG 1396_ DWSDE 1401_ KDCGD 1406_ SHILP 1411_ FSTPG 1416_ PSTCL 1421_ PNYYR 1426_ CSSGT 1431_ CVMDT 1436_ WVCDG 1441_ YRDCA 1446_ DGSDE 1451_ EACPL 1456_ LANVT 1461_ AASTP 1466_ TQLGR 1471_ CDRFE 1476_ FECHQ 1481_ PKTCI 1486_ PNWKR 1491_ CDGHQ 1496_ DCQDG 1501_ RDEAN 1506_ CPTHS 1511_ TLTCM 1516_ SREFQ 1521_ CEDGE 1526_ ACIVL 1531_ SERCD 1536_ GFLDC 1541_ SDESD 1546_ EKACS 1551_ DELTV 1556_ YKVQN 1561_ LQWTA 1566_ DFSGD 1571_ VTLTW 1576_ MRPKK 1581_ MPSAS 1586_ CVYNV 1591_ YYRVV 1596_ GESIW 1601_ KTLET 1606_ HSNKT 1611_ NTVLK 1616_ VLKPD 1621_ TTYQV 1626_ KVQVQ 1631_ CLSKA 1636_ HNTND 1641_ FVTLR 1646_ TPEGL 1651_ PDAPR 1656_ NLQLS 1661_ LPREA 1666_ EGVIV 1671_ GHWAP 1676_ PIHTH 1681_ GLIRE 1686_ YIVEY 1691_ SRSGS 1696_ KMWAS 1701_ QRAAS 1706_ NFTEI 1711_ KNLLV 1716_ NTLYT 1721_ VRVAA 1726_ VTSRG 1731_ IGNWS 1736_ DSKSI 1741_ TTIKG 1746_ KVIPP 1751_ PDIHI 1756_ DSYGE 1761_ NYLSF 1766_ TLTME 1771_ SDIKV 1776_ NGYVV 1781_ NLFWA 1786_ FDTHK 1791_ QERRT 1796_ LNFRG 1801_ SILSH 1806_ KVGNL 1811_ TAHTS 1816_ YEISA 1821_ WAKTD 1826_ LGDSP 1831_ LAFEH 1836_ VMTRG 1841_ VRPPA 1846_ PSLKA 1851_ KAINQ 1856_ TAVEC 1861_ TWTGP 1866_ RNVVY 1871_ GIFYA 1876_ TSFLD 1881_ LYRNP 1886_ KSLTT 1891_ SLHNK 1896_ TVIVS 1901_ KDEQY 1906_ LFLVR 1911_ VVVPY 1916_ QGPSS 1921_ DYVVV 1926_ KMIPD 1931_ SRLPP 1936_ RHLHV 1941_ VHTGK 1946_ TSVVI 1951_ KWESP 1956_ YDSPD 1961_ QDLLY 1966_ AVAVK 1971_ DLIRK 1976_ TDRSY 1981_ KVKSR 1986_ NSTVE 1991_ YTLNK 1996_ LEPGG 2001_ KYHII 2006_ VQLGN 2011_ MSKDS 2016_ SIKIT 2021_ TVSLS 2026_ APDAL 2031_ KIITE 2036_ NDHVL 2041_ LFWKS 2046_ LALKE 2051_ KHFNE 2056_ SRGYE 2061_ IHMFD 2066_ SAMNI 2071_ TAYLG 2076_ NTTDN 2081_ FFKIS 2086_ NLKMG 2091_ HNYTF 2096_ TVQAR 2101_ CLFGN 2106_ QICGE 2111_ PAILL 2116_ YDELG 2121_ SGADA 2126_ SATQA 2131_ ARSTD 2136_ VAAVV 2141_ VPILF 2146_ LILLS 2151_ LGVGF 2156_ AILYT 2161_ KHRRL 2166_ QSSFT 2171_ AFANS 2176_ HYSSR 2181_ LGSAI 2186_ FSSGD 2191_ DLGED 2196_ DEDAP 2201_ MITGF 2206_SDDVP
1: Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (PubMed:17855360). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation (PubMed:31138794). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (PubMed:18603531). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (PubMed:14764453). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (PubMed:23486467). Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003)