Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
1_MARAA 6_ ALLPS 11_ RSPPT 16_ PLLWP 21_ LLLLL 26_ LLETG 31_ AQDVR 36_ VQVLP 41_ EVRGQ 46_ LGGTV 51_ ELPCH 56_ LLPPV 61_ PGLYI 66_ SLVTW 71_ QRPDA 76_ PANHQ 81_ NVAAF 86_ HPKMG 91_ PSFPS 96_ PKPGS 101_ ERLSF 106_ VSAKQ 111_ STGQD 116_ TEAEL 121_ QDATL 126_ ALHGL 131_ TVEDE 136_ GNYTC 141_ EFATF 146_ PKGSV 151_ RGMTW 156_ LRVIA 161_ KPKNQ 166_ AEAQK 171_ VTFSQ 176_ DPTTV 181_ ALCIS 186_ KEGRP 191_ PARIS 196_ WLSSL 201_ DWEAK 206_ ETQVS 211_ GTLAG 216_ TVTVT 221_ SRFTL 226_ VPSGR 231_ ADGVT 236_ VTCKV 241_ EHESF 246_ EEPAL 251_ IPVTL 256_ SVRYP 261_ PEVSI 266_ SGYDD 271_ NWYLG 276_ RTDAT 281_ LSCDV 286_ RSNPE 291_ PTGYD 296_ WSTTS 301_ GTFPT 306_ SAVAQ 311_ GSQLV 316_ IHAVD 321_ SLFNT 326_ TFVCT 331_ VTNAV 336_ GMGRA 341_ EQVIF 346_ VRETP 351_ NTAGA 356_ GATGG 361_ IIGGI 366_ IAAII 371_ ATAVA 376_ ATGIL 381_ ICRQQ 386_ RKEQT 391_ LQGAE 396_ EDEDL 401_ EGPPS 406_ YKPPT 411_ PKAKL 416_ EAQEM 421_ PSQLF 426_ TLGAS 431_ EHSPL 436_ KTPYF 441_ DAGAS 446_ CTEQE 451_ MPRYH 456_ ELPTL 461_ EERSG 466_ PLHPG 471_ ATSLG 476_ SPIPV 481_ PPGPP 486_ AVEDV 491_ SLDLE 496_ DEEGE 501_ EEEEY 506_ LDKIN 511_ PIYDA 516_ LSYSS 521_ PSDSY 526_ QGKGF 531_VMSRA
1: Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005)
2: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV)