DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)
1_MRRSL 6_ APSQL 11_ AKRKP 16_ EGRSC 21_ DDEDW 26_ QPGLV 31_ TPRKR 36_ KSSSE 41_ TQIQE 46_ CFLSP 51_ FRKPL 56_ SQLTN 61_ QPPCL 66_ DSSQH 71_ EAFIR 76_ SILSK 81_ PFKVP 86_ IPNYQ 91_ GPLGS 96_ RALGL 101_ KRAGV 106_ RRALH 111_ DPLEK 116_ DALVL 121_ YEPPP 126_ LSAHD 131_ QLKLD 136_ KEKLP 141_ VHVVV 146_ DPILS 151_ KVLRP 156_ HQREG 161_ VKFLW 166_ ECVTS 171_ RRIPG 176_ SHGCI 181_ MADEM 186_ GLGKT 191_ LQCIT 196_ LMWTL 201_ LRQSP 206_ ECKPE 211_ IDKAV 216_ VVSPS 221_ SLVKN 226_ WYNEV 231_ GKWLG 236_ GRIQP 241_ LAIDG 246_ GSKDE 251_ IDQKL 256_ EGFMN 261_ QRGAR 266_ VSSPI 271_ LIISY 276_ ETFRL 281_ HVGVL 286_ QKGSV 291_ GLVIC 296_ DEGHR 301_ LKNSE 306_ NQTYQ 311_ ALDSL 316_ NTSRR 321_ VLISG 326_ TPIQN 331_ DLLEY 336_ FSLVH 341_ FVNSG 346_ ILGTA 351_ HEFKK 356_ HFELP 361_ ILKGR 366_ DAAAS 371_ EADRQ 376_ LGEER 381_ LRELT 386_ SIVNR 391_ CLIRR 396_ TSDIL 401_ SKYLP 406_ VKIEQ 411_ VVCCR 416_ LTPLQ 421_ TELYK 426_ RFLRQ 431_ AKPAE 436_ ELLEG 441_ KMSVS 446_ SLSSI 451_ TSLKK 456_ LCNHP 461_ ALIYD 466_ KCVEE 471_ EDGFV 476_ GALDL 481_ FPPGY 486_ SSKAL 491_ EPQLS 496_ GKMLV 501_ LDYIL 506_ AVTRS 511_ RSSDK 516_ VVLVS 521_ NYTQT 526_ LDLFE 531_ KLCRA 536_ RRYLY 541_ VRLDG 546_ TMSIK 551_ KRAKV 556_ VERFN 561_ SPSSP 566_ DFVFM 571_ LSSKA 576_ GGCGL 581_ NLIGA 586_ NRLVM 591_ FDPDW 596_ NPAND 601_ EQAMA 606_ RVWRD 611_ GQKKT 616_ CYIYR 621_ LLSAG 626_ TIEEK 631_ IFQRQ 636_ SHKKA 641_ LSSCV 646_ VDEEQ 651_ DVERH 656_ FSLGE 661_ LKELF 666_ ILDEA 671_ SLSDT 676_ HDRLH 681_ CRRCV 686_ NSRQI 691_ RPPPD 696_ GSDCT 701_ SDLAG 706_ WNHCT 711_ DKWGL 716_ RDEVL 721_ QAAWD 726_ AASTA 731_ ITFVF 736_ HQRSH 741_EEQRG
1: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11459989, PubMed:12205100, PubMed:24798879, PubMed:27264870, PubMed:32457312, PubMed:9774452). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity)