Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
1_MCENQ 6_ LKTKA 11_ DATAQ 16_ IEVIP 21_ CKICG 26_ DKSSG 31_ IHYGV 36_ ITCEG 41_ CKGFF 46_ RRSQQ 51_ NNASY 56_ SCPRQ 61_ RNCLI 66_ DRTNR 71_ NRCQH 76_ CRLQK 81_ CLALG 86_ MSRDA 91_ VKFGR 96_ MSKKQ 101_ RDSLY 106_ AEVQK 111_ HQQRL 116_ QEQRQ 121_ QQSGE 126_ AEALA 131_ RVYSS 136_ SISNG 141_ LSNLN 146_ NETSG 151_ TYANG 156_ HVIDL 161_ PKSEG 166_ YYNVD 171_ SGQPS 176_ PDQSG 181_ LDMTG 186_ IKQIK 191_ QEPIY 196_ DLTSV 201_ PNLFT 206_ YSSFN 211_ NGQLA 216_ PGITM 221_ TEIDR 226_ IAQNI 231_ IKSHL 236_ ETCQY 241_ TMEEL 246_ HQLAW 251_ QTHTY 256_ EEIKA 261_ YQSKS 266_ REALW 271_ QQCAI 276_ QITHA 281_ IQYVV 286_ EFAKR 291_ ITGFM 296_ ELCQN 301_ DQILL 306_ LKSGC 311_ LEVVL 316_ VRMCR 321_ AFNPL 326_ NNTVL 331_ FEGKY 336_ GGMQM 341_ FKALG 346_ SDDLV 351_ NEAFD 356_ FAKNL 361_ CSLQL 366_ TEEEI 371_ ALFSS 376_ AVLIS 381_ PDRAW 386_ LIEPR 391_ KVQKL 396_ QEKIY 401_ FALQH 406_ VIQKN 411_ HLDDE 416_ TLAKL 421_ IAKIP 426_ TITAV 431_ CNLHG 436_ EKLQV 441_ FKQSH 446_ PEIVN 451_ TLFPP 456_ LYKEL 461_FNPDC
1: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
2: Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity)