Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1)
1_MLWKI 6_ TDNVK 11_ YEEDC 16_ EDRHD 21_ GSSNG 26_ NPRVP 31_ HLSSA 36_ GQHLY 41_ SPAPP 46_ LSHTG 51_ VAEYQ 56_ PPPYF 61_ PPPYQ 66_ QLAYS 71_ QSADP 76_ YSHLG 81_ EAYAA 86_ AINPL 91_ HQPAP 96_ TGSQQ 101_ QAWPG 106_ RQSQE 111_ GAGLP 116_ SHHGR 121_ PAGLL 126_ PHLSG 131_ LEAGA 136_ VSARR 141_ DAYRR 146_ SDLLL 151_ PHAHA 156_ LDAAG 161_ LAENL 166_ GLHDM 171_ PHQMD 176_ EVQNV 181_ DDQHL 186_ LLHDQ 191_ TVIRK 196_ GPISM 201_ TKNPL 206_ NLPCQ 211_ KELVG 216_ AVMNP 221_ TEVFC 226_ SVPGR 231_ LSLLS 236_ STSKY 241_ KVTVA 246_ EVQRR 251_ LSPPE 256_ CLNAS 261_ LLGGV 266_ LRRAK 271_ SKNGG 276_ RSLRE 281_ KLDKI 286_ GLNLP 291_ AGRRK 296_ AAHVT 301_ LLTSL 306_ VEGEA 311_ VHLAR 316_ DFAYV 321_ CEAEF 326_ PSKPV 331_ AEYLT 336_ RPHLG 341_ GRNEM 346_ AARKN 351_ MLLAA 356_ QQLCK 361_ EFTEL 366_ LSQDR 371_ TPHGT 376_ SRLAP 381_ VLETN 386_ IQNCL 391_ SHFSL 396_ ITHGF 401_ GSQAI 406_ CAAVS 411_ ALQNY 416_ IKEAL 421_ IVIDK 426_ SYMNP 431_ GDQSP 436_ ADSNK 441_TLEKM
1: Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532)