General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)
1_MESTP 6_ SRGLN 11_ RVHLQ 16_ CRNLQ 21_ EFLGG 26_ LSPGV 31_ LDRLY 36_ GHPAT 41_ CLAVF 46_ RELPS 51_ LAKNW 56_ VMRML 61_ FLEQP 66_ LPQAA 71_ VALWV 76_ KKEFS 81_ KAQEE 86_ STGLL 91_ SGLRI 96_ WHTQL 101_ LPGGL 106_ QGLIL 111_ NPIFR 116_ QNLRI 121_ ALLGG 126_ GKAWS 131_ DDTSQ 136_ LGPDK 141_ HARDV 146_ PSLDK 151_ YAEER 156_ WEVVL 161_ HFMVG 166_ SPSAA 171_ VSQDL 176_ AQLLS 181_ QAGLM 186_ KSTEP 191_ GEPPC 196_ ITSAG 201_ FQFLL 206_ LDTPA 211_ QLWYF 216_ MLQYL 221_ QTAQS 226_ RGMDL 231_ VEILS 236_ FLFQL 241_ SFSTL 246_ GKDYS 251_ VEGMS 256_ DSLLN 261_ FLQHL 266_ REFGL 271_ VFQRK 276_ RKSRR 281_ YYPTR 286_ LAINL 291_ SSGVS 296_ GAGGT 301_ VHQPG 306_ FIVVE 311_ TNYRL 316_ YAYTE 321_ SELQI 326_ ALIAL 331_ FSEML 336_ YRFPN 341_ MVVAQ 346_ VTRES 351_ VQQAI 356_ ASGIT 361_ AQQII 366_ HFLRT 371_ RAHPV 376_ MLKQT 381_ PVLPP 386_ TITDQ 391_ IRLWE 396_ LERDR 401_ LRFTE 406_ GVLYN 411_ QFLSQ 416_ VDFEL 421_ LLAHA 426_ RELGV 431_ LVFEN 436_ SAKRL 441_ MVVTP 446_ AGHSD 451_ VKRFW 456_KRQKH
1: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription
2: Stimulates the ATPase activity of TFIIH subunit XPB/ERCC3 (PubMed:17466626)