Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
1_MAYSQ 6_ GGGKK 11_ KVCYY 16_ YDGDI 21_ GNYYY 26_ GQGHP 31_ MKPHR 36_ IRMTH 41_ NLLLN 46_ YGLYR 51_ KMEIY 56_ RPHKA 61_ TAEEM 66_ TKYHS 71_ DEYIK 76_ FLRSI 81_ RPDNM 86_ SEYSK 91_ QMQRF 96_ NVGED 101_ CPVFD 106_ GLFEF 111_ CQLST 116_ GGSVA 121_ GAVKL 126_ NRQQT 131_ DMAVN 136_ WAGGL 141_ HHAKK 146_ SEASG 151_ FCYVN 156_ DIVLA 161_ ILELL 166_ KYHQR 171_ VLYID 176_ IDIHH 181_ GDGVE 186_ EAFYT 191_ TDRVM 196_ TVSFH 201_ KYGEY 206_ FPGTG 211_ DLRDI 216_ GAGKG 221_ KYYAV 226_ NFPMR 231_ DGIDD 236_ ESYGQ 241_ IFKPI 246_ ISKVM 251_ EMYQP 256_ SAVVL 261_ QCGAD 266_ SLSGD 271_ RLGCF 276_ NLTVK 281_ GHAKC 286_ VEVVK 291_ TFNLP 296_ LLMLG 301_ GGGYT 306_ IRNVA 311_ RCWTY 316_ ETAVA 321_ LDCEI 326_ PNELP 331_ YNDYF 336_ EYFGP 341_ DFKLH 346_ ISPSN 351_ MTNQN 356_ TPEYM 361_ EKIKQ 366_ RLFEN 371_ LRMLP 376_ HAPGV 381_ QMQAI 386_ PEDAV 391_ HEDSG 396_ DEDGE 401_ DPDKR 406_ ISIRA 411_ SDKRI 416_ ACDEE 421_ FSDSE 426_ DEGEG 431_ GRRNV 436_ ADHKK 441_ GAKKA 446_ RIEED 451_ KKETE 456_ DKKTD 461_ VKEED 466_ KSKDN 471_ SGEKT 476_ DTKGT 481_KSEQL
1: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827)