Retinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (Short chain dehydrogenase/reductase family 9C member 5)
1_MWLPL 6_ LLGAL 11_ LWAVL 16_ WLLRD 21_ RQSLP 26_ ASNAF 31_ VFITG 36_ CDSGF 41_ GRLLA 46_ LQLDQ 51_ RGFRV 56_ LASCL 61_ TPSGA 66_ EDLQR 71_ VASSR 76_ LHTTL 81_ LDITD 86_ PQSVQ 91_ QAAKW 96_ VEMHV 101_ KEAGL 106_ FGLVN 111_ NAGVA 116_ GIIGP 121_ TPWLT 126_ RDDFQ 131_ RVLNV 136_ NTMGP 141_ IGVTL 146_ ALLPL 151_ LQQAR 156_ GRVIN 161_ ITSVL 166_ GRLAA 171_ NGGGY 176_ CVSKF 181_ GLEAF 186_ SDSLR 191_ RDVAH 196_ FGIRV 201_ SIVEP 206_ GFFRT 211_ PVTNL 216_ ESLEK 221_ TLQAC 226_ WARLP 231_ PATQA 236_ HYGGA 241_ FLTKY 246_ LKMQQ 251_ RIMNL 256_ ICDPD 261_ LTKVS 266_ RCLEH 271_ ALTAR 276_ HPRTR 281_ YSPGW 286_ DAKLL 291_ WLPAS 296_ YLPAS 301_ LVDAV 306_ LTWVL 311_PKPAQ
1: Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:11675386, PubMed:9115228, PubMed:9931293). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:29541409, PubMed:9931293)