Zinc finger protein neuro-d4 (BRG1-associated factor 45B) (BAF45B) (D4, zinc and double PHD fingers family 1)
1_MATVI 6_ PGPLS 11_ LGEDF 16_ YREAI 21_ EHCRS 26_ YNARL 31_ CAERS 36_ LRLPF 41_ LDSQT 46_ GVAQN 51_ NCYIW 56_ MEKTH 61_ RGPGL 66_ APGQI 71_ YTYPA 76_ RCWRK 81_ KRRLN 86_ ILEDP 91_ RLRPC 96_ EYKID 101_ CEAPL 106_ KKEGG 111_ LPEGP 116_ VLEAL 121_ LCAET 126_ GEKKI 131_ ELKEE 136_ ETIMD 141_ CQKQQ 146_ LLEFP 151_ HDLEV 156_ EDLED 161_ DIPRR 166_ KNRAK 171_ GKAYG 176_ IGGLR 181_ KRQDT 186_ ASLED 191_ RDKPY 196_ VCDIC 201_ GKRYK 206_ NRPGL 211_ SYHYT 216_ HTHLA 221_ EEEGE 226_ ENAER 231_ HALPF 236_ HRKNN 241_ HKQFY 246_ KELAW 251_ VPEAQ 256_ RKHTA 261_ KKAPD 266_ GTVIP 271_ NGYCD 276_ FCLGG 281_ SKKTG 286_ CPEDL 291_ ISCAD 296_ CGRSG 301_ HPSCL 306_ QFTVN 311_ MTAAV 316_ RTYRW 321_ QCIEC 326_ KSCSL 331_ CGTSE 336_ NDDQL 341_ LFCDD 346_ CDRGY 351_ HMYCL 356_ SPPMA 361_ EPPEG 366_ SWSCH 371_ LCLRH 376_ LKEKA 381_SAYIT
1: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)