Signal transducing adapter molecule 1 (STAM-1)
1_MPLFA 6_ TNPFD 11_ QDVEK 16_ ATSEM 21_ NTAED 26_ WGLIL 31_ DICDK 36_ VGQSR 41_ TGPKD 46_ CLRSI 51_ MRRVN 56_ HKDPH 61_ VAMQA 66_ LTLLG 71_ ACVSN 76_ CGKIF 81_ HLEVC 86_ SRDFA 91_ SEVSN 96_ VLNKG 101_ HPKVC 106_ EKLKA 111_ LMVEW 116_ TDEFK 121_ NDPQL 126_ SLISA 131_ MIKNL 136_ KEQGV 141_ TFPAI 146_ GSQAA 151_ EQAKA 156_ SPALV 161_ AKDPG 166_ TVANK 171_ KEEED 176_ LAKAI 181_ ELSLK 186_ EQRQQ 191_ STTLS 196_ TLYPS 201_ TSSLL 206_ TNHQH 211_ EGRKV 216_ RAIYD 221_ FEAAE 226_ DNELT 231_ FKAGE 236_ IITVL 241_ DDSDP 246_ NWWKG 251_ ETHQG 256_ IGLFP 261_ SNFVT 266_ ADLTA 271_ EPEMI 276_ KTEKK 281_ TVQFS 286_ DDVQV 291_ ETIEP 296_ EPEPA 301_ FIDED 306_ KMDQL 311_ LQMLQ 316_ STDPS 321_ DDQPD 326_ LPELL 331_ HLEAM 336_ CHQMG 341_ PLIDE 346_ KLEDI 351_ DRKHS 356_ ELSEL 361_ NVKVM 366_ EALSL 371_ YTKLM 376_ NEDPM 381_ YSMYA 386_ KLQNQ 391_ PYYMQ 396_ SSGVS 401_ GSQVY 406_ AGPPP 411_ SGAYL 416_ VAGNA 421_ QMSHL 426_ QSYSL 431_ PPEQL 436_ SSLSQ 441_ AVVPP 446_ SANPA 451_ LPSQQ 456_ TQAAY 461_ PNTMV 466_ SSVQG 471_ NTYPS 476_ QAPVY 481_ SPPPA 486_ ATAAA 491_ ATADV 496_ TLYQN 501_ AGPNM 506_ PQVPN 511_ YNLTS 516_ STLPQ 521_ PGGSQ 526_ QPPQP 531_QQPYS
1: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes
2: (Microbial infection) Plays an important role in Dengue virus entry