Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4)
1_MATVI 6_ HNPLK 11_ ALGDQ 16_ FYKEA 21_ IEHCR 26_ SYNSR 31_ LCAER 36_ SVRLP 41_ FLDSQ 46_ TGVAQ 51_ NNCYI 56_ WMEKR 61_ HRGPG 66_ LAPGQ 71_ LYTYP 76_ ARCWR 81_ KKRRL 86_ HPPED 91_ PKLRL 96_ LEIKP 101_ EVELP 106_ LKKDG 111_ FTSES 116_ TTLEA 121_ LLRGE 126_ GVEKK 131_ VDARE 136_ EESIQ 141_ EIQRV 146_ LENDE 151_ NVEEG 156_ NEEED 161_ LEEDI 166_ PKRKN 171_ RTRGR 176_ ARGSA 181_ GGRRR 186_ HDAAS 191_ QEDHD 196_ KPYVC 201_ DICGK 206_ RYKNR 211_ PGLSY 216_ HYAHT 221_ HLASE 226_ EGDEA 231_ QDQET 236_ RSPPN 241_ HRNEN 246_ HRPQK 251_ GPDGT 256_ VIPNN 261_ YCDFC 266_ LGGSN 271_ MNKKS 276_ GRPEE 281_ LVSCA 286_ DCGRS 291_ GHPTC 296_ LQFTL 301_ NMTEA 306_ VKTYK 311_ WQCIE 316_ CKSCI 321_ LCGTS 326_ ENDDQ 331_ LLFCD 336_ DCDRG 341_ YHMYC 346_ LNPPV 351_ AEPPE 356_ GSWSC 361_ HLCWE 366_ LLKEK 371_ASAFG
1: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development
2: Acts as a regulator of myogenesis in cooperation with HDGFL2 (PubMed:32459350). Mediates the interaction of HDGFL2 with the BAF complex (PubMed:32459350). HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350)