Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)
1_MPDHD 6_ STALL 11_ SRQTK 16_ RRRVD 21_ IGVKR 26_ TVGTA 31_ SAFFA 36_ KARAT 41_ FFSAM 46_ NPQGS 51_ EQDVE 56_ YSVVQ 61_ HADGE 66_ KSNVL 71_ RKLLK 76_ RANSY 81_ EDAMM 86_ PFPGA 91_ TIISQ 96_ LLKNN 101_ MNKNG 106_ GTEPS 111_ FQASG 116_ LSSTG 121_ SEVHQ 126_ EDICS 131_ NSSRD 136_ SPPEC 141_ LSPFG 146_ RPTMS 151_ QFDMD 156_ RLCDE 161_ HLRAK 166_ RARVE 171_ NIIRG 176_ MSHSP 181_ SVALR 186_ GNENE 191_ REMAP 196_ QSVSP 201_ RESYR 206_ ENKRK 211_ QKLPQ 216_ QQQQS 221_ FQQLV 226_ SARKE 231_ QKREE 236_ RRQLK 241_ QQLED 246_ MQKQL 251_ RQLQE 256_ KFYQI 261_ YDSTD 266_ SENDE 271_ DGNLS 276_ EDSMR 281_ SEILD 286_ ARAQD 291_ SVGRS 296_ DNEMC 301_ ELDPG 306_ QFIDR 311_ ARALI 316_ REQEM 321_ AENKP 326_ KREGN 331_ NKERD 336_ HGPNS 341_ LQPEG 346_ KHLAE 351_ TLKQE 356_ LNTAM 361_ SQVVD 366_ TVVKV 371_ FSAKP 376_ SRQVP 381_ QVFPP 386_ LQIPQ 391_ ARFAV 396_ NGENH 401_ NFHTA 406_ NQRLQ 411_ CFGDV 416_ IIPNP 421_ LDTFG 426_ NVQMA 431_ SSTDQ 436_ TEALP 441_ LVVRK 446_ NSSDQ 451_ SASGP 456_ AAGGH 461_ HQPLH 466_ QSPLS 471_ ATTGF 476_ TTSTF 481_ RHPFP 486_ LPLMA 491_ YPFQS 496_ PLGAP 501_ SGSFS 506_ GKDRA 511_ SPESL 516_ DLTRD 521_ TTSLR 526_ TKMSS 531_ HHLSH 536_ HPCSP 541_ AHPPS 546_ TAEGL 551_ SLSLI 556_ KSECG 561_ DLQDM 566_ SEISP 571_ YSGSA 576_ MQEGL 581_ SPNHL 586_ KKAKL 591_ MFFYT 596_ RYPSS 601_ NMLKT 606_ YFSDV 611_ KFNRC 616_ ITSQL 621_ IKWFS 626_ NFREF 631_ YYIQM 636_ EKYAR 641_ QAIND 646_ GVTST 651_ EELSI 656_ TRDCE 661_ LYRAL 666_ NMHYN 671_ KANDF 676_ EVPER 681_ FLEVA 686_ QITLR 691_ EFFNA 696_ IIAGK 701_ DVDPS 706_ WKKAI 711_ YKVIC 716_ KLDSE 721_ VPEIF 726_ KSPNC 731_LQELL
1: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3