Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65)
1_MARVA 6_ WGLLW 11_ LLLGS 16_ AGAQY 21_ EKYSF 26_ RGFPP 31_ EDLMP 36_ LAAAY 41_ GHALE 46_ QYEGE 51_ SWRES 56_ ARYLE 61_ AALRL 66_ HRLLR 71_ DSEAF 76_ CHANC 81_ SGPAP 86_ AAKPD 91_ PDGGR 96_ ADEWA 101_ CELRL 106_ FGRVL 111_ ERAAC 116_ LRRCK 121_ RTLPA 126_ FQVPY 131_ PPRQL 136_ LRDFQ 141_ SRLPY 146_ QYLHY 151_ ALFKA 156_ NRLEK 161_ AVAAA 166_ YTFLQ 171_ RNPKH 176_ ELTAK 181_ YLNYY 186_ QGMLD 191_ VADES 196_ LTDLE 201_ AQPYE 206_ AVFLR 211_ AVKLY 216_ NSGDF 221_ RSSTE 226_ DMERA 231_ LSEYL 236_ AVFAR 241_ CLAGC 246_ EGAHE 251_ QVDFK 256_ DFYPA 261_ IADLF 266_ AESLQ 271_ CKVDC 276_ EANLT 281_ PNVGG 286_ YFVDK 291_ FVATM 296_ YHYLQ 301_ FAYYK 306_ LNDVR 311_ QAARS 316_ AASYM 321_ LFDPK 326_ DSVMQ 331_ QNLVY 336_ YRFHR 341_ ARWGL 346_ EEEDF 351_ QPREE 356_ AMLYH 361_ NQTAE 366_ LRELL 371_ EFTHM 376_ YLQSD 381_ DEMEL 386_ EETEP 391_ PLEPE 396_ DALSD 401_ AEFEG 406_ EGDYE 411_ EGMYA 416_ DWWQE 421_ PDAKG 426_ DEAEA 431_EPEPE
1: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly