CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
1_MAENL 6_ LDGPP 11_ NPKRA 16_ KLSSP 21_ GFSAN 26_ DSTDF 31_ GSLFD 36_ LENDL 41_ PDELI 46_ PNGGE 51_ LGLLN 56_ SGNLV 61_ PDAAS 66_ KHKQL 71_ SELLR 76_ GGSGS 81_ SINPG 86_ IGNVS 91_ ASSPV 96_ QQGLG 101_ GQAQG 106_ QPNSA 111_ NMASL 116_ SAMGK 121_ SPLSQ 126_ GDSSA 131_ PSLPK 136_ QAAST 141_ SGPTP 146_ AASQA 151_ LNPQA 156_ QKQVG 161_ LATSS 166_ PATSQ 171_ TGPGI 176_ CMNAN 181_ FNQTH 186_ PGLLN 191_ SNSGH 196_ SLINQ 201_ ASQGQ 206_ AQVMN 211_ GSLGA 216_ AGRGR 221_ GAGMP 226_ YPTPA 231_ MQGAS 236_ SSVLA 241_ ETLTQ 246_ VSPQM 251_ TGHAG 256_ LNTAQ 261_ AGGMA 266_ KMGIT 271_ GNTSP 276_ FGQPF 281_ SQAGG 286_ QPMGA 291_ TGVNP 296_ QLASK 301_ QSMVN 306_ SLPTF 311_ PTDIK 316_ NTSVT 321_ NVPNM 326_ SQMQT 331_ SVGIV 336_ PTQAI 341_ ATGPT 346_ ADPEK 351_ RKLIQ 356_ QQLVL 361_ LLHAH 366_ KCQRR 371_ EQANG 376_ EVRAC 381_ SLPHC 386_ RTMKN 391_ VLNHM 396_ THCQA 401_ GKACQ 406_ VAHCA 411_ SSRQI 416_ ISHWK 421_ NCTRH 426_ DCPVC 431_ LPLKN 436_ ASDKR 441_ NQQTI 446_ LGSPA 451_ SGIQN 456_ TIGSV 461_ GTGQQ 466_ NATSL 471_ SNPNP 476_ IDPSS 481_ MQRAY 486_ AALGL 491_ PYMNQ 496_ PQTQL 501_ QPQVP 506_ GQQPA 511_ QPQTH 516_ QQMRT 521_ LNPLG 526_ NNPMN 531_ IPAGG 536_ ITTDQ 541_ QPPNL 546_ ISESA 551_ LPTSL 556_ GATNP 561_ LMNDG 566_ SNSGN 571_ IGTLS 576_ TIPTA 581_ APPSS 586_ TGVRK 591_ GWHEH 596_ VTQDL 601_ RSHLV 606_ HKLVQ 611_ AIFPT 616_ PDPAA 621_ LKDRR 626_ MENLV 631_ AYAKK 636_ VEGDM 641_ YESAN 646_ SRDEY 651_ YHLLA 656_ EKIYK 661_ IQKEL 666_ EEKRR 671_ SRLHK 676_ QGILG 681_ NQPAL 686_ PAPGA 691_ QPPVI 696_ PQAQP 701_ VRPPN 706_ GPLSL 711_ PVNRM 716_ QVSQG 721_ MNSFN 726_ PMSLG 731_ NVQLP 736_ QAPMG 741_ PRAAS 746_ PMNHS 751_ VQMNS 756_ MGSVP 761_ GMAIS 766_ PSRMP 771_ QPPNM 776_ MGAHT 781_ NNMMA 786_ QAPAQ 791_ SQFLP 796_ QNQFP 801_ SSSGA 806_ MSVGM 811_ GQPPA 816_ QTGVS 821_ QGQVP 826_ GAALP 831_ NPLNM 836_ LGPQA 841_ SQLPC 846_ PPVTQ 851_ SPLHP 856_ TPPPA 861_ STAAG 866_ MPSLQ 871_ HTTPP 876_ GMTPP 881_ QPAAP 886_ TQPST 891_ PVSSS 896_ GQTPT 901_ PTPGS 906_ VPSAT 911_ QTQST 916_ PTVQA 921_ AAQAQ 926_ VTPQP 931_ QTPVQ 936_ PPSVA 941_ TPQSS 946_ QQQPT 951_ PVHAQ 956_ PPGTP 961_ LSQAA 966_ ASIDN 971_ RVPTP 976_ SSVAS 981_ AETNS 986_ QQPGP 991_ DVPVL 996_ EMKTE 1001_ TQAED 1006_ TEPDP 1011_ GESKG 1016_ EPRSE 1021_ MMEED 1026_ LQGAS 1031_ QVKEE 1036_ TDIAE 1041_ QKSEP 1046_ MEVDE 1051_ KKPEV 1056_ KVEVK 1061_ EEEES 1066_ SSNGT 1071_ ASQST 1076_ SPSQP 1081_ RKKIF 1086_ KPEEL 1091_ RQALM 1096_ PTLEA 1101_ LYRQD 1106_ PESLP 1111_ FRQPV 1116_ DPQLL 1121_ GIPDY 1126_ FDIVK 1131_ NPMDL 1136_ STIKR 1141_ KLDTG 1146_ QYQEP 1151_ WQYVD 1156_ DVWLM 1161_ FNNAW 1166_ LYNRK 1171_ TSRVY 1176_ KFCSK 1181_ LAEVF 1186_ EQEID 1191_ PVMQS 1196_ LGYCC 1201_ GRKYE 1206_ FSPQT 1211_ LCCYG 1216_ KQLCT 1221_ IPRDA 1226_ AYYSY 1231_ QNRYH 1236_ FCEKC 1241_ FTEIQ 1246_ GENVT 1251_ LGDDP 1256_ SQPQT 1261_ TISKD 1266_ QFEKK 1271_ KNDTL 1276_ DPEPF 1281_ VDCKE 1286_ CGRKM 1291_ HQICV 1296_ LHYDI 1301_ IWPSG 1306_ FVCDN 1311_ CLKKT 1316_ GRPRK 1321_ ENKFS 1326_ AKRLQ 1331_ TTRLG 1336_ NHLED 1341_ RVNKF 1346_ LRRQN 1351_ HPEAG 1356_ EVFVR 1361_ VVASS 1366_ DKTVE 1371_ VKPGM 1376_ KSRFV 1381_ DSGEM 1386_ SESFP 1391_ YRTKA 1396_ LFAFE 1401_ EIDGV 1406_ DVCFF 1411_ GMHVQ 1416_ EYGSD 1421_ CPPPN 1426_ TRRVY 1431_ ISYLD 1436_ SIHFF 1441_ RPRCL 1446_ RTAVY 1451_ HEILI 1456_ GYLEY 1461_ VKKLG 1466_ YVTGH 1471_ IWACP 1476_ PSEGD 1481_ DYIFH 1486_ CHPPD 1491_ QKIPK 1496_ PKRLQ 1501_ EWYKK 1506_ MLDKA 1511_ FAERI 1516_ IHDYK 1521_ DIFKQ 1526_ ATEDR 1531_ LTSAK 1536_ ELPYF 1541_ EGDFW 1546_ PNVLE 1551_ ESIKE 1556_ LEQEE 1561_ EERKK 1566_ EESTA 1571_ ASETT 1576_ EGSQG 1581_ DSKNA 1586_ KKKNN 1591_ KKTNK 1596_ NKSSI 1601_ SRANK 1606_ KKPSM 1611_ PNVSN 1616_ DLSQK 1621_ LYATM 1626_ EKHKE 1631_ VFFVI 1636_ HLHAG 1641_ PVINT 1646_ LPPIV 1651_ DPDPL 1656_ LSCDL 1661_ MDGRD 1666_ AFLTL 1671_ ARDKH 1676_ WEFSS 1681_ LRRSK 1686_ WSTLC 1691_ MLVEL 1696_ HTQGQ 1701_ DRFVY 1706_ TCNEC 1711_ KHHVE 1716_ TRWHC 1721_ TVCED 1726_ YDLCI 1731_ NCYNT 1736_ KSHAH 1741_ KMVKW 1746_ GLGLD 1751_ DEGSS 1756_ QGEPQ 1761_ SKSPQ 1766_ ESRRL 1771_ SIQRC 1776_ IQSLV 1781_ HACQC 1786_ RNANC 1791_ SLPSC 1796_ QKMKR 1801_ VVQHT 1806_ KGCKR 1811_ KTNGG 1816_ CPVCK 1821_ QLIAL 1826_ CCYHA 1831_ KHCQE 1836_ NKCPV 1841_ PFCLN 1846_ IKHKL 1851_ RQQQI 1856_ QHRLQ 1861_ QAQLM 1866_ RRRMA 1871_ TMNTR 1876_ NVPQQ 1881_ SLPSP 1886_ TSAPP 1891_ GTPTQ 1896_ QPSTP 1901_ QTPQP 1906_ PAQPQ 1911_ PSPVS 1916_ MSPAG 1921_ FPSVA 1926_ RTQPP 1931_ TTVST 1936_ GKPTS 1941_ QVPAP 1946_ PPPAQ 1951_ PPPAA 1956_ VEAAR 1961_ QIERE 1966_ AQQQQ 1971_ HLYRV 1976_ NINNS 1981_ MPPGR 1986_ TGMGT 1991_ PGSQM 1996_ APVSL 2001_ NVPRP 2006_ NQVSG 2011_ PVMPS 2016_ MPPGQ 2021_ WQQAP 2026_ LPQQQ 2031_ PMPGL 2036_ PRPVI 2041_ SMQAQ 2046_ AAVAG 2051_ PRMPS 2056_ VQPPR 2061_ SISPS 2066_ ALQDL 2071_ LRTLK 2076_ SPSSP 2081_ QQQQQ 2086_ VLNIL 2091_ KSNPQ 2096_ LMAAF 2101_ IKQRT 2106_ AKYVA 2111_ NQPGM 2116_ QPQPG 2121_ LQSQP 2126_ GMQPQ 2131_ PGMHQ 2136_ QPSLQ 2141_ NLNAM 2146_ QAGVP 2151_ RPGVP 2156_ PQQQA 2161_ MGGLN 2166_ PQGQA 2171_ LNIMN 2176_ PGHNP 2181_ NMASM 2186_ NPQYR 2191_ EMLRR 2196_ QLLQQ 2201_ QQQQQ 2206_ QQQQQ 2211_ QQQQQ 2216_ QGSAG 2221_ MAGGM 2226_ AGHGQ 2231_ FQQPQ 2236_ GPGGY 2241_ PPAMQ 2246_ QQQRM 2251_ QQHLP 2256_ LQGSS 2261_ MGQMA 2266_ AQMGQ 2271_ LGQMG 2276_ QPGLG 2281_ ADSTP 2286_ NIQQA 2291_ LQQRI 2296_ LQQQQ 2301_ MKQQI 2306_ GSPGQ 2311_ PNPMS 2316_ PQQHM 2321_ LSGQP 2326_ QASHL 2331_ PGQQI 2336_ ATSLS 2341_ NQVRS 2346_ PAPVQ 2351_ SPRPQ 2356_ SQPPH 2361_ SSPSP 2366_ RIQPQ 2371_ PSPHH 2376_ VSPQT 2381_ GSPHP 2386_ GLAVT 2391_ MASSI 2396_ DQGHL 2401_ GNPEQ 2406_ SAMLP 2411_ QLNTP 2416_ SRSAL 2421_ SSELS 2426_ LVGDT 2431_ TGDTL 2436_EKFVE
1: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493)