Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
1_MEIPN 6_ PPTSK 11_ CITYW 16_ KRKVK 21_ SEYMR 26_ LRQLK 31_ RLQAN 36_ MGAKA 41_ LYVAN 46_ FAKVQ 51_ EKTQI 56_ LNEEW 61_ KKLRV 66_ QPVQS 71_ MKPVS 76_ GHPFL 81_ KKCTI 86_ ESIFP 91_ GFASQ 96_ HMLMR 101_ SLNTV 106_ ALVPI 111_ MYSWS 116_ PLQQN 121_ FMVED 126_ ETVLC 131_ NIPYM 136_ GDEVK 141_ EEDET 146_ FIEEL 151_ INNYD 156_ GKVHG 161_ EEEMI 166_ PGSVL 171_ ISDAV 176_ FLELV 181_ DALNQ 186_ YSDEE 191_ EEGHN 196_ DTSDG 201_ KQDDS 206_ KEDLP 211_ VTRKR 216_ KRHAI 221_ EGNKK 226_ SSKKQ 231_ FPNDM 236_ IFSAI 241_ ASMFP 246_ ENGVP 251_ DDMKE 256_ RYREL 261_ TEMSD 266_ PNALP 271_ PQCTP 276_ NIDGP 281_ NAKSV 286_ QREQS 291_ LHSFH 296_ TLFCR 301_ RCFKY 306_ DCFLH 311_ PFHAT 316_ PNVYK 321_ RKNKE 326_ IKIEP 331_ EPCGT 336_ DCFLL 341_ LEGAK 346_ EYAML 351_ HNPRS 356_ KCSGR 361_ RRRRH 366_ HIVSA 371_ SCSNA 376_ SASAV 381_ AETKE 386_ GDSDR 391_ DTGND 396_ WASSS 401_ SEANS 406_ RCQTP 411_ TKQKA 416_ SPAPP 421_ QLCVV 426_ EAPSE 431_ PVEWT 436_ GAEES 441_ LFRVF 446_ HGTYF 451_ NNFCS 456_ IARLL 461_ GTKTC 466_ KQVFQ 471_ FAVKE 476_ SLILK 481_ LPTDE 486_ LMNPS 491_ QKKKR 496_ KHRLW 501_ AAHCR 506_ KIQLK 511_ KDNSS 516_ TQVYN 521_ YQPCD 526_ HPDRP 531_ CDSTC 536_ PCIMT 541_ QNFCE 546_ KFCQC 551_ NPDCQ 556_ NRFPG 561_ CRCKT 566_ QCNTK 571_ QCPCY 576_ LAVRE 581_ CDPDL 586_ CLTCG 591_ ASEHW 596_ DCKVV 601_ SCKNC 606_ SIQRG 611_ LKKHL 616_ LLAPS 621_ DVAGW 626_ GTFIK 631_ ESVQK 636_ NEFIS 641_ EYCGE 646_ LISQD 651_ EADRR 656_ GKVYD 661_ KYMSS 666_ FLFNL 671_ NNDFV 676_ VDATR 681_ KGNKI 686_ RFANH 691_ SVNPN 696_ CYAKV 701_ VMVNG 706_ DHRIG 711_ IFAKR 716_ AIQAG 721_ EELFF 726_ DYRYS 731_ QADAL 736_ KYVGI 741_ERETD
1: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation